- ￥1350 - 2250
- EnkiLife
- AMRe02423
- 2025年11月23日
- WB
- Rabbit
- Human;Mouse;Rat
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- 详细信息
- 技术资料
- 标记物：
Unconjugated
- 适应物种：
Human;Mouse;Rat
- 供应商：
武汉恩玑生命科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB
- 规格：
50uL/100uL
| 规格： | 50uL | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100uL | 产品价格： | ￥2250.0 |
产品概述
产品性能
免疫原
产品应用
研究背景
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
研究领域
Epigenetics and Nuclear Signaling
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