Cullin 5 (CUL5) Rabbit Monoclo

ProductName：Cullin 5 (CUL5) Rabbit Monoclonal Antibody [Clone ID: R02-5K8]
description：Cullin 5 Rabbit monoclonal Antibody
symbol：CUL5
synonyms：CUL-5; VACM-1; VACM1
locusid：8065
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：Q93034
Applications：WB
CNdelivery：2周
RecommendDilution：WB: 1/1000-1/5000
Reactivity：Human, Mouse, Rat
Immunogen：Recombinant protein of human Cullin 5
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：cullin 5
Background：Swiss-Prot Acc.Q93034.Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 91 kDa; Observed MW: 91 kDa