- 详细信息
- 文献和实验
- 技术资料
- 供应商:
万类生物
- 靶点:
cleaved N-terminal GSDMD
- 克隆性:
多克隆
- 抗原来源:
兔
- 保质期:
一年
- 抗体英文名:
cleaved N-terminal GSDMD ntibody
- 抗体名:
cleaved N-terminal GSDMD抗体
- 标记物:
无
- 宿主:
兔
- 适应物种:
HMR
- 亚型:
IgG
- 形态:
液体
- 应用范围:
WB,IHC,IF
- 保存条件:
-20℃
- 浓度:
>1 mg/ml
- 规格:
50μl(>50μg)
产品概述
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical inflammasome activators.After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine.
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文献和实验Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan
Neoepitope antibodies recognize the newly created N or C terminus of protein degradation products but fail to recognize the same sequence of amino acids present in intact or undigested protein. Aggrecan neoepitope antibodies have been pivotal
Antibodies to MMP-Cleaved Aggrecan
specificity for antigenic determinants on the newly created N- or C- termini of the degradation products. By definition, these “neoepitope” antibodies recognize a terminal sequence exclusively and do not recognize the same sequence of amino acids located
Nature 子刊 | 「老药新用」戒酒药还能治疗脓毒症?抑制细胞焦亡新选择
,从而达到戒酒的目的。而最近,科学家们发现双硫仑对脓毒症的治疗也可能发挥重要作用。 炎症小体异常激活与多种人类疾病有关,包括炎症性肠病、痛风、II 型糖尿病、心血管疾病、阿茨海默病和脓毒症,而脓毒症通常是全身感染的致命反应,引发炎症小体异常激活。 Gasdermin D(GSDMD)是炎性小体激活下游的最后一个共同效应蛋白,在 N - 末端域(GSDMD-NT)和自抑制的 C - 末端域(GSDMD-CT)的交界处被 caspases 裂解。GSDMD-NT 可结合质膜内面的酸性磷脂
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