Nectin-4慢病毒-Nectin-4 Lentiviru

Nectin-4 ADC成功之后，NECTIN家族还有哪些“宝藏成员”？

NECTIN家族是一组属于免疫球蛋白超家族（immunoglobulin superfamily, IgSF）的细胞黏附分子，参与细胞间识别、细胞连接形成以及组织结构维持等重要过程。与经典钙黏蛋白主要依赖钙离子介导细胞连接不同，NECTIN家族通过多样化的同源和异源分子结合方式，参与更加复杂的细胞间通讯。 随着研究深入，NECTIN家族的功能已由传统的细胞黏附逐渐拓展至神经系统发育、病毒感染、免疫调控及肿瘤发生发展等多个领域。不同成员虽然具有相似的结构基础，但由于表达模式、结合伙伴以及下游信号

From Lentiviruses to Lentivirus Vectors

Although a member of the lentivirus group, the equine infectious anemia virus (EIAV) was the first nonplant virus discovered in the first decade of the 20th century (1 ), lentiviruses were considered as rather mysterious viruses

Hybrid Lentivirus Vectors

Lentivirus vectors are promising tools for gene transfer (1 ,2 ). Retroviral vectors in general offer the unique advantage of stably integrating into the genome of the host cell, thus providing the basis for sustained gene expression