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- 详细信息
- 文献和实验
- 技术资料
- 浓度:
Recommended Dilutions:Western Blotting (WB): 1:1,000-1:5,000 Flow Cytometry (FCM): 1:2,000
- 应用范围:
Western Blotting (WB), Flow Cytometry (FCM)
- 宿主:
兔
- 适应物种:
Human
- 保质期:
One year
- 克隆性:
Rabbit mAb
- 保存条件:
Store at -20 °C for one year. Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
- 形态:
液体
- 亚型:
Rabbit IgG
- 免疫原:
A synthesized peptide derived from human GRB7
- 规格:
20ul/50ul/100ul
| 规格: | 20ul | 产品价格: | ¥620.0 |
|---|---|---|---|
| 规格: | 50ul | 产品价格: | ¥1200.0 |
| 规格: | 100ul | 产品价格: | ¥2200.0 |
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文献和实验Grb2蛋白(growth factor receptor-bound protein 2)
Grb2是生长因子受体结合蛋白2,又叫Ash蛋白。该蛋白参与细胞内各种受体激活后的下游调节。它能够直接与激活的表皮生长因子受体磷酸化的酪氨酸结合,参与EGF受体介导的信号转导,也能通过与Shc磷酸化的酪氨酸结合间接参与由胰岛素受体介导的信号转导。Grb2能够同时与Shc、Sos结合形成Shc-Grb2-Sos复合物,并将Sos激活,激活的Sos与质膜上的Ras蛋白结合,并将其激活,引起信号级联反应。Grb2蛋白含有一个SH2结构域和两个SH3结构域,属SH蛋白。
【翻译】Development trends for monoclonal antibody cancer therapeutics
of action. The other five products function through alternative primary modes of action (blockade of growth factor–receptor interaction, receptor downmodulation and inhibition of signalling). Again, it should be noted that mAbs are not necessarily restricted
Chimerization of a Monoclonal Antibody for Treating Hodgkin's Lymphoma
Ber-H2 which recognizes the human CD30 molecule with high specificity and affinity (2 ). CD30, a member of the nerve growth factor (NGF) tumor necrosis factor receptor (TNFR) superfamily (3 ), is strongly expressed on the pathognomonic Hodgkin (H
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