AML 193细胞

AML 193细胞AML 193人急性单核细胞白血病细胞

Cell line name AML-193

Synonyms AML193

Accession CVCL_1071

Resource Identification Initiative To cite this cell line use: AML-193 (RRID:CVCL_1071)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9589.

Population: African American and Caucasian.

Characteristics: CSF2, IL3 and IL6 dependent.

Doubling time: 65 hours (PubMed=25984343); ~50-60 hours (DSMZ=ACC-549).

Omics: Deep exome analysis.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Mutation; HGNC; HGNC:25657; BCORL1; Simple; p.Arg784Ter (c.2350C>T); Zygosity=Unspecified (PubMed=21989985; DepMap=ACH-000557).

Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Val (c.38G>T); ClinVar=VCV000375876; Zygosity=Heterozygous (PubMed=12068308; DepMap=ACH-000557).

Mutation; HGNC; HGNC:11998; TP53; Simple; c.993+2T>G (IVS9+2T>G); ClinVar=VCV000635384; Zygosity=Unspecified; Note=Splice donor mutation (DepMap=ACH-000557).

PubMed=3496132; DOI=10.1182/blood.V70.1.192.192

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Blood 70:192-199(1987)

 

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PubMed=2015403; DOI=10.1182/blood.V77.8.1804.1804

Valtieri M., Boccoli G., Testa U., Barletta C., Peschle C.

Two-step differentiation of AML-193 leukemic line: terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF.

Blood 77:1804-1812(1991)

 

PubMed=9195772; DOI=10.1016/s0925-5710(96)00563-4

Tohyama K.

Human factor-dependent leukemia cell lines.

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DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

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(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

 

PubMed=12068308; DOI=10.1038/nature00766

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PubMed=16408098; DOI=10.1038/sj.leu.2404081

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JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Leukemia 20:471-476(2006)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

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PubMed=21989985; DOI=10.1182/blood-2011-05-356204; PMCID=PMC3228503

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Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.

Blood 118:5914-5917(2011)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)