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文献和实验The Path to Oncology Drug Target Validation: An Industry Perspective
The advent of a variety of genomic, proteomic and other system-based scientific approaches has raised the expectations of identifying novel targets for oncology drug discovery. However, the complexity of human genome cancer alterations
Coating DNA with RecA Protein to Distinguish DNA Path by Electron Microscopy
To understand, at the molecular level, the mechanism of enzymes that act on DNA, it is highly informative to know the topology of their substrates and products. To describe fully the topology of a DNA knot or catenane, it is necessary to know
Scanning fluorescence correlation spectroscopy (SFCS) with a scan path perpendicular to the membrane plane was introduced to measure diffusion and interactions of fluorescent components in free-standing biomembranes. Using a confocal laser
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