- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- DMC101110B
- 2025年07月08日
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit/Human Fc chimeric IgG1
- 形态：
Powder
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性：
Monoclonal
- 标记物：
Biotinylated
- 适应物种：
Human
- 保质期：
12个月
- 级别：
仅用于科研
- 库存：
2-3 weeks
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Rabbit
- 靶点：
FLT3
- 抗体英文名：
Biotinylated Anti-FLT3 antibody(19A5), IgG1 Chimeric mAb
- 抗体名：
Biotinylated Anti-FLT3 antibody(19A5), IgG1 Chimeric mAb
- 规格：
50μg
| SKU | DMC101110B |
|---|---|
| 产品分类 | Monoclonal Antibodies |
| 规格 | Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00 |
| 背景 | Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. |
| Clone ID | 19A5 |
| 别名 | Flt-3;Flk-2;STK-1;CD135;FLK2;FLT-3 |
| 应用 | Flow Cyt |
| 形态与组成成分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | Flow Cyt 1/100 |
| 靶点 | FLT3 |
| Uniprot ID | P36888 |
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
【翻译】Development trends for monoclonal antibody cancer therapeutics
(ADCC) and complement-dependent cytotoxicity (CDC), respectively, and are mediated through the Fc portion of mAbs. Some mAb isotypes (human IgG1 and IgG3, and murine IgG2a) are potentially more competent than others at inducing ADCC and CDC3, 26, 28
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