- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- DMC100267
- 2025年07月14日
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit/Human Fc chimeric IgG1
- 形态：
Powder
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12个月
- 级别：
仅用于科研
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Rabbit
- 靶点：
TNFSF11
- 抗体英文名：
Anti-TNFSF11 antibody(DMC267); IgG1 Chimeric mAb
- 抗体名：
Anti-TNFSF11 antibody(DMC267); IgG1 Chimeric mAb
- 规格：
50μg
| SKU | DMC100267 |
|---|---|
| 产品分类 | Monoclonal Antibodies |
| 规格 | Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00 |
| 背景 | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT:PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6; which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes; and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
| Clone ID | DMC267 |
| 别名 | CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE |
| 应用 | Flow Cyt |
| 形态与组成成分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | Flow Cyt 1:100 |
| 靶点 | TNFSF11 |
| Uniprot ID | O14788 |
Figure 1. Flow cytometry analysis with Anti-TNFSF11 (DMC267) on Expi293 cells transfected with human TNFSF11 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
【翻译】Development trends for monoclonal antibody cancer therapeutics
(ADCC) and complement-dependent cytotoxicity (CDC), respectively, and are mediated through the Fc portion of mAbs. Some mAb isotypes (human IgG1 and IgG3, and murine IgG2a) are potentially more competent than others at inducing ADCC and CDC3, 26, 28
【资源】全面归类网址：毕赤酵母表达各种来源蛋白（细菌，真菌，植物，人类等）
propeptideS, 10 mg/L, α-MF[215, 216]Cathepsin VS, α-MF[217]Cathepsin XS, 5 mg/L, α-MF, activable417CD14S, 20 mg/L,α-MF, active414, 550CD38S, 455 mg/L, α-MF[218]CD40 ligand soluble formS, 255 mg/L[219]CD140, solubleS, α-MF, functional522Chimeric B7-2 antibody
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