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- DIMA BIOTECH/缔码生物
- 武汉
- FLP120168
- 2025年09月28日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C to -80°C
- 保质期：
12个月
- 英文名：
Human 5HT2C-Strep full length protein-synthetic nanodisc
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
10μg
| 货号 | FLP120168 |
|---|---|
| 产品分类 | Full Length Transmembrane Proteins |
| 价格&规格 | Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00 |
| 背景 | The protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. |
| 描述 | Human 5HT2C-Strep full length protein-synthetic nanodisc |
| 分子量 | The human full length 5HT2C-Strep protein has a MW of 51.8 kDa |
| 蛋白家族 | Druggable Genome, GPCR, Transmembrane |
| 信号通路 | Calcium signaling pathway, Gap junction, Neuroactive ligand-receptor interaction |
| 别名 | 5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C |
| 标签 | C-Flag&Strep Tag |
| 是否偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 形式 | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| 靶点 | 5HT2C |
| Uniprot ID | P28335 |
| 用途 | Research use only |
验证图
Figure 1. Elisa plates were pre-coated with C-Flag&Strep Tag 5HT2C-Strep-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with 5HT2C-Strep-nanodisc is 1.549ng/ml.
Figure 2. Human 5HT2C-Strep-Nanodisc, C-Flag&Strep Tag on SDS-PAGE
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文献和实验Characterization of 5‐HT1A,B and 5‐HT2A,C Serotonin Receptor Binding
., Morse, B., Whitman, M.M., Ivanshchenko, Y., Jaye, M., and Felder, S. 1991. Cloning of the human serotonin 5‐HT2 and 5‐HT1C receptor subtypes. Biochem. Biophys. Res. Commun. . 181:1469‐1478.
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receptor8. Mouse apoB is a large protein of 4,515 amino acids and is expressed predominantly in liver and jejunum. apoB mRNA is subject to post-transcriptional editing, and the unedited and edited transcripts encode the full-length protein apoB-100
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