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- DIMA BIOTECH/缔码生物
- 武汉
- FLP110098
- 2025年07月09日
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- 技术资料
- 保存条件：
-20°C to -80°C
- 保质期：
12个月
- 英文名：
Human MBP-AGTR1 full length protein-synthetic nanodisc
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
10μg
| 货号 | FLP110098 |
|---|---|
| 产品分类 | Full Length Transmembrane Proteins |
| 价格&规格 | Price: 10 μg ￥6300.00 ; 50 μg ￥30000.00 ; 100 μg ￥55000.00 |
| 背景 | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. |
| 描述 | Human MBP-AGTR1 full length protein-synthetic nanodisc |
| 分子量 | The human full length MBP-AGTR1 protein has a MW of 81.1 kDa |
| 蛋白家族 | Druggable Genome, GPCR, Transmembrane |
| 信号通路 | Calcium signaling pathway, Neuroactive ligand-receptor interaction, Renin-angiotensin system, Vascular smooth muscle contraction |
| 别名 | AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R |
| 标签 | N-MBP Tag, C-Flag Tag |
| 是否偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 形式 | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| 靶点 | AGTR1 |
| Uniprot ID | P30556 |
| 用途 | Research use only |
验证图
Figure 1. Elisa plates were pre-coated with N-MBP Tag, C-Flag Tag MBP-AGTR1-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with MBP-AGTR1-Nanodisc is 4.309ng/ml.
Figure 2. Human MBP-AGTR1-Nanodisc with N-MBP Tag, C-Flag Tag on SDS-PAGE
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