- 询价
- AntibodySystem
- DHH34799
- France
- 2025年07月11日
- Research Grade Biosimilar
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Murlentamab-MMAE (ADC)
- 抗体英文名：
Murlentamab-MMAE (ADC)
- 浓度：
1 mg/ml
- 应用范围：
Research Grade Biosimilar
- 适应物种：
Human
- 保质期：
1 year
- 级别：
科研级
- 库存：
999
- 供应商：
AntibodySystem
- 克隆性：
Monoclonal
- 保存条件：
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- 形态：
Liquid
- 规格：
100ug
| 描述 | Murlentamab-MMAE is an ADC consisting of an AMHR2-directed antibody and Monomethyl auristatin E (MMAE) used for the study of colorectal cancer and ovarian cancer. |
| 种属反应性 | Human |
| 状态 | Liquid |
| 浓度 | 1 mg/ml |
| 纯度 | >90% as determined by SEC. |
| 克隆类型 | Monoclonal |
| 应用 | Research Grade Biosimilar |
| 靶标 | MIS type II receptor, MISR2, AMHR2, AMHR, Anti-Muellerian hormone type II receptor, MRII, AMH type II receptor, MISRII, Anti-Muellerian hormone type-2 receptor |
| 纯化方式 | Purified by Ion Exchange Chromatography. |
| 内毒素水平 | Please contact with the lab for this information. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 克隆号 | Murlentamab-MMAE |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
Our products are designed for various research areas, supporting studies on 48 types of viruses, superbugs, parasites, cancer, Alzheimer's disease, Parkinson's disease, allergic responses, immune suppression, and immune activation.
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文献和实验从Physiological Reviews看ADC设计全链条，华美生物高质量试剂如何助力ADC研发全流程
一、ADC作用机制：从血液循环到肿瘤杀伤的五步链 ADC的经典作用模式（MoA）是一个精密的多步骤过程： Step 1 靶向结合 — ADC通过抗体部分特异性识别肿瘤细胞表面的靶抗原（TAA），实现肿瘤富集 Step 2 内吞入胞 — ADC-受体复合物经网格蛋白/小窝蛋白介导的内吞作用进入细胞 Step 3 溶酶体降解 — 晚期内吞体与溶酶体融合（pH 4.7），ADC被降解 Step 4 释放Payload — 酸性环境或组织蛋白酶切割连接子，释放活性毒素
MMAE (HY-15162) www.medchemexpress.cn/Monomethyl-auristatin-E.html ADC Payload Dxd (HY-13631D) www.medchemexpress.cn/Dxd.html ADC Payload Exatecan (HY-13631) www.medchemexpress.cn/exatecan.html ADC Payload
AntibodyDrug Conjugate (ADC) Clinical Pipeline: A Review
them to small molecule drugs. This combination is expected to bring together the benefits of highly potent drugs on the one hand and selective binders of specific tumor antigens on the other hand. However, designing an ADC is more complex than a simple meccano
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