NCIH524细胞

NCI-H524/NCI-H524细胞系/NCI-H524细胞株/NCI-H524人非小细胞肺癌细胞

Cell line name NCI-H524

Synonyms H524; H-524; NCIH524

Accession CVCL_1568

Resource Identification Initiative To cite this cell line use: NCI-H524 (RRID:CVCL_1568)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: 100 hours (PubMed=25984343).

Microsatellite instability: Instable (MSI-low) (Sanger).

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

PubMed=6713399

Rosen S.T., Mulshine J.L., Cuttitta F., Fedorko J., Carney D.N., Gazdar A.F., Minna J.D.

Analysis of human small cell lung cancer differentiation antigens using a panel of rat monoclonal antibodies.

Cancer Res. 44:2052-2061(1984)

 

PubMed=2985257

Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J., Moody T.W., Zweig M.H., Minna J.D.

Establishment and identification of small cell lung cancer cell lines having classic and variant features.

Cancer Res. 45:2913-2923(1985)

 

PubMed=2985258

Gazdar A.F., Carney D.N., Nau M.M., Minna J.D.

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.

Cancer Res. 45:2924-2930(1985)

 

PubMed=2473086; DOI=10.1242/jcs.91.1.91

Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H., Carney D.N., Vooijs G.P., Ramaekers F.C.S.

Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines.

J. Cell Sci. 91:91-108(1988)

 

PubMed=3335022

Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Cancer Res. 48:589-601(1988)

 

PubMed=2388294; DOI=10.1093/jnci/82.17.1420

McLemore T.L., Litterst C.L., Coudert B.P., Liu M.C., Hubbard W.C., Adelberg S., Czerwinski M.J., McMahon N.A., Eggleston J.C., Boyd M.R.

Metabolic activation of 4-ipomeanol in human lung, primary pulmonary carcinomas, and established human pulmonary carcinoma cell lines.

J. Natl. Cancer Inst. 82:1420-1426(1990)

 

PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y

Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A., Boerman O.C., Ramaekers F.C.S.

Novel antigens characteristic of neuroendocrine malignancies.

Cancer 67:619-633(1991)

 

PubMed=1320893; DOI=10.1159/000163712

Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M., Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M., Burbach J.P.H.

Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.

Pathobiology 60:136-142(1992)

 

PubMed=7720728

Senden N.H.M., van de Velde H.J.K., Broers J.L.V., Timmer E.D.J., Kuijpers H.J.H., Roebroek A.J.M., van de Ven W.J.M., Ramaekers F.C.S.

Subcellular localization and supramolecular organization of neuroendocrine-specific protein B (NSP-B) in small cell lung cancer.

Eur. J. Cell Biol. 65:341-353(1994)

 

PubMed=8806092; DOI=10.1002/jcb.240630505

Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.

NCI-Navy Medical Oncology Branch cell line data base.

J. Cell. Biochem. Suppl. 24:32-91(1996)

 

PubMed=8806103; DOI=10.1002/jcb.240630516

Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

J. Cell. Biochem. Suppl. 24:210-217(1996)