IMR32细胞

IMR-32/IMR-32细胞系/IMR-32细胞株/IMR-32人神经母细胞瘤细胞

Cell line name IMR-32

Synonyms IMR 32; IMR32; Institute for Medical Research-32; GM03320; GM3320C; GM03320D; AG03320; AG3320

Accession CVCL_0346

Resource Identification Initiative To cite this cell line use: IMR-32 (RRID:CVCL_0346)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Population: Caucasian.

Characteristics: Neuroblastic type (N-type).

Doubling time: 48 hours (PubMed=5459762); ~20 hours (ATCC=CCL-127); ~40-50 hours (DSMZ=ACC-165).

Omics: Array-based CGH.

Omics: Cell surface proteome.

Omics: Deep exome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: IMR-92; Note=Occasionally.

Misspelling: IRM-32; Note=Occasionally.

Derived from site: Metastatic; Abdomen; UBERON=UBERON_0000916.

HLA typing Source: PubMed=26589293

Class I

HLA-A A*24:02,24:02

HLA-B B*07:05,07:05

HLA-C C*05:01,12:03

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0

Native American 0.56

East Asian, North 1.01

East Asian, South 0

South Asian 3.99

European, North 73.7

European, South 20.72

Disease Neuroblastoma (NCIt: C3270)

Neuroblastoma (ORDO: Orphanet_635)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

PubMed=7838528

Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.

Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.

Oncogene 10:291-297(1995)

 

PubMed=8665486; DOI=10.1016/0304-3835(96)04250-4

Diccianni M.B., Chau L.S., Batova A., Vu T.Q., Yu A.L.-T.

The p16 and p18 tumor suppressor genes in neuroblastoma: implications for drug resistance.

Cancer Lett. 104:183-192(1996)

 

PubMed=9201287

Cinatl J. Jr., Hernaiz Driever P., Cinatl J., Ruckert D.G., Gumbel H.O., Rabenau H.F., Kornhuber B., Doerr H.-W.

Increased efficacy of aphidicolin killing of human neuroblastoma cells in vitro by encapsulation in liposomes.

Neoplasma 44:91-95(1997)

 

PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7

Van Roy N., Jauch A., Van Gele M., Laureys G., Versteeg R., De Paepe A., Cremer T., Speleman F.

Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.

Cancer Genet. Cytogenet. 97:135-142(1997)

 

PubMed=9516836; DOI=10.1016/S0959-8049(97)00319-5

Van Roy N., Laureys G., Van Gele M., Opdenakker G., Miura R., van der Drift P., Chan A., Versteeg R., Speleman F.

Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.

Eur. J. Cancer 33:1974-1978(1997)

 

DOI=10.1007/0-306-46872-7_2

Thiele C.J.

Neuroblastoma.

(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

 

PubMed=11550280; DOI=10.1002/gcc.1174

Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B., Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Genes Chromosomes Cancer 32:126-135(2001)

 

PubMed=11668190; DOI=10.1177/002215540104901105

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

Immunocytochemical analysis of cell lines derived from solid tumors.

J. Histochem. Cytochem. 49:1369-1378(2001)

 

PubMed=12210830; DOI=10.1002/jnr.10330

Yoshida S., Narita T., Taga T., Ohta S., Takeuchi Y.

Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.

J. Neurosci. Res. 69:642-652(2002)

 

PubMed=12702577

Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.

PPM1D is a potential target for 17q gain in neuroblastoma.

Cancer Res. 63:1876-1883(2003)

 

PubMed=15390183; DOI=10.1002/gcc.20096

Gebauer S., Yu A.L.-T., Omura-Minamisawa M., Batova A., Diccianni M.B.

Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma.

Genes Chromosomes Cancer 41:297-308(2004)