B16

B16/B16细胞系/B16细胞株/B16小鼠黑色素瘤细胞

Cell line name    B16
Synonyms    B-16; B16 melanoma; B16 subline B78; B78
Accession    CVCL_F936
Resource Identification Initiative    To cite this cell line use: B16 (RRID:CVCL_F936)
Comments    Doubling time: ~28 hours (Note=Lot 07242000), 20-21 hours (Note=Lot 06122003), ~1 day (Note=Lot 10062005), ~20 hours (Note=Lot 03232009), ~27 hours (Note=Lot 03312017), ~33 hours (Note=Lot 01122021) (JCRB=JCRB0202).
Miscellaneous: This line seems to be the B78 line described in PubMed=4981070 which itself seems to be derived from the HFH-18 line that itself originate from a B16 melanoma.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Disease    Mouse melanoma (NCIt: C21790)
Species of origin    Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy    Parent: CVCL_GS32 (HFH-18)
Children:
CVCL_4612 (B16 melanoma 4A5)    CVCL_L291 (B16 melanoma/lacZ)    CVCL_8298 (B16-A)
CVCL_8299 (B16-B)    CVCL_H720 (B16-C2M)    CVCL_H721 (B16-C2W)
CVCL_0604 (B16-F0)    CVCL_WM78 (B16-MO4)    CVCL_WM77 (B16-MO5)
CVCL_1950 (B16V)    CVCL_8341 (B78H1)    CVCL_D6AV (HyCyte B16 KO-mTnfaip8)
CVCL_4772 (MEB-4)
Sex of cell    Male
Category    Cancer cell line
Publications    
PubMed=4981070; DOI=10.1083/jcb.43.2.263; PMCID=PMC2107859
Silagi S.
Control of pigment production in mouse melanoma cells in vitro Evocation and maintenance.
J. Cell Biol. 43:263-274(1969)

PubMed=5513504; DOI=10.1093/jnci/45.4.789
Stephenson E.M., Stephenson N.G.
Karyotype analysis of the B16 mouse melanoma with reassessment of the normal mouse idiogram.
J. Natl. Cancer Inst. 45:789-800(1970)

PubMed=1109790
Fidler I.J.
Biological behavior of malignant melanoma cells correlated to their survival in vivo.
Cancer Res. 35:218-224(1975)

PubMed=6498800; DOI=10.1016/0304-3835(84)90080-6
Wosko T.J., Ferrara D.T., Sartori L.S.
Histological comparison of the B16 melanoma and its F1 variant.
Cancer Lett. 24:57-63(1984)