RWPE2细胞

【ATCC来源】RWPE-2、RWPE-2、RWPE-2细胞、RWPE-2细胞、RWPE-2RWPE-2[人前列腺正常细胞]

Cell line name RWPE-2

Synonyms RWPE2

Accession CVCL_3792

Resource Identification Initiative To cite this cell line use: RWPE-2 (RRID:CVCL_3792)

Comments Group: Patented cell line.

Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11610.

Population: Caucasian.

Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P01117; Kirsten murine sarcoma virus k-Ras (Ki-ras).

Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).

Omics: SNP array analysis.

Derived from site: In situ; Prostate, epithelium; UBERON=UBERON_0000428.

Cell type: Epithelial cell of prostate; CL=CL_0002231.

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Parent: CVCL_3791 (RWPE-1)

Children:

CVCL_3793 (RWPE2-W99)

Sex of cell Male

Age at sampling 54Y

Category Transformed cell line

STR profile Source(s): ATCC=CRL-3608

 

Markers:

Amelogenin X,Y

CSF1PO 13

D5S818 12,15

D7S820 10,11

D13S317 8,14

D16S539 9,11

TH01 8,9.3

TPOX 8,11

vWA 14,18

 

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Publications

PubMed=9018337; DOI=10.1002/(SICI)1097-0045(19970101)30:1<58::AID-PROS9>3.0.CO;2-H

Webber M.M., Bello D., Quader S.T.A.

Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications Part 2. Tumorigenic cell lines.

Prostate 30:58-64(1997)

 

PubMed=9214605; DOI=10.1093/carcin/18.6.1215

Bello D., Webber M.M., Kleinman H.K., Wartinger D.D., Rhim J.S.

Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18.

Carcinogenesis 18:1215-1223(1997)

 

PubMed=9214606; DOI=10.1093/carcin/18.6.1225

Webber M.M., Bello D., Kleinman H.K., Hoffman M.P.

Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells.

Carcinogenesis 18:1225-1231(1997)

 

Patent=US6255058

Webber M.M., Rhim J.S.

Immortalized and malignant human prostatic cell lines.

Patent number US6255058, 03-Jul-2001

 

PubMed=12725112; DOI=10.1385/1-59259-372-0:21

Russell P.J., Kingsley E.A.

Human prostate cancer cell lines.

Methods Mol. Med. 81:21-39(2003)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)