MKN7细胞

MKN7、MKN-7、MKN7细胞、MKN-7细胞、MKN7人胃癌细胞

Cell line name MKN7

Synonyms MKN-7; MKN 7

Accession CVCL_1417

Resource Identification Initiative To cite this cell line use: MKN7 (RRID:CVCL_1417)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: JFCR39 cancer cell line panel.

Part of: JFCR45 cancer cell line panel.

Population: Japanese.

Doubling time: 64-66 hours (PubMed=3962675); 66 hours (PubMed=29435981); 86 hours (PubMed=25984343).

Microsatellite instability: Instable (MSI-low) (Sanger).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Caution: TP53 mutation indicated incorrectly as being at p.Ile251Leu (c.751A>C) in PubMed=15900046.

Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ser (c.832C>T); ClinVar=VCV000376642; Zygosity=Homozygous (PubMed=11107048; Cosmic-CLP=924250; DepMap=ACH-000678).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*24:02,24:02

HLA-B B*07:02,48:01

HLA-C C*04:01,08:03

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0

Native American 0.09

East Asian, North 81.05

East Asian, South 18.37

South Asian 0

European, North 0

European, South 0.49

Disease Gastric tubular adenocarcinoma (NCIt: C5473)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_4Y05 (MKN7/CMV-Luc)

Sex of cell Male

Age at sampling 39Y

Category Cancer cell line

STR profile Source(s): Cosmic-CLP=924250; JCRB=JCRB1025; PubMed=25877200; RCB=RCB0999; TKG=TKG 0228

 

Markers:

Amelogenin X

CSF1PO 10,13

D3S1358 17

D5S818 9,13

D7S820 9 (JCRB=JCRB1025; PubMed=25877200; TKG=TKG 0228)

9,11 (Cosmic-CLP=924250; RCB=RCB0999)

D8S1179 15

D13S317 8,12

D16S539 9,10

D18S51 13,18

D21S11 29,32.2

FGA 23

Penta D 10,11

Penta E 18

TH01 7,9

TPOX 9

vWA 17

PubMed=1933850

Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S., Nakatani K., Nakano H., Sugimura T., Terada M.

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

Cancer Res. 51:5800-5805(1991)

 

DOI=10.1016/B978-0-12-333530-2.50014-9

Sekiguchi M., Suzuki T.

Gastric tumor cell lines.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994)

 

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x

Yokozaki H.

Molecular characteristics of eight gastric cancer cell lines established in Japan.

Pathol. Int. 50:767-777(2000)

 

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020

Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Cancer Sci. 96:100-110(2005)

 

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234

Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.

Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.

Mol. Cancer Ther. 4:399-412(2005)

 

PubMed=15900046; DOI=10.1093/jnci/dji133

Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y., Tomoda H., Yamori T., Tsuruo T.

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

J. Natl. Cancer Inst. 97:765-777(2005)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)