SKNMC细胞

SK-N-MC/SK-N-MC细胞系/SK-N-MC细胞株/SK-N-MC人神经上皮瘤细胞

Cell line name SK-N-MC

Synonyms SKNMC; SK-NM-C; SK-NMC

Accession CVCL_0530

Resource Identification Initiative To cite this cell line use: SK-N-MC (RRID:CVCL_0530)

Comments Problematic cell line: Misclassified. Originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor (PubMed=20143388).

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: ENCODE project common cell types; tier 3.

From: Memorial Sloan Kettering Cancer Center; New York; USA.

Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00267.

Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 776.

Population: Caucasian.

Doubling time: 32 hours (PubMed=4748425); 23 hours (PubMed=24312454); ~32 hours (CLS=300340); ~48 hours (DSMZ=ACC-203).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.

PubMed=7459858

Rousset M., Zweibaum A., Fogh J.

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.

Cancer Res. 41:1165-1170(1981)

 

PubMed=7037175

Reynolds C.P., Reynolds D.A., Frenkel E.P., Smith R.G.

Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.

Cancer Res. 42:1331-1336(1982)

 

DOI=10.1016/B978-0-12-008304-6.50015-4

Biedler J.L., Meyers M.B., Spengler B.A.

Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.

(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983)

 

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720

Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.

Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.

Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

 

PubMed=2987426; DOI=10.1007/BF00165170

Helson L., Helson C.

Human neuroblastoma cells and 13-cis-retinoic acid.

J. Neurooncol. 3:39-41(1985)

 

PubMed=3518877; DOI=10.3109/07357908609038260

Fogh J.

Human tumor lines for cancer research.

Cancer Invest. 4:157-184(1986)

 

PubMed=2784858; DOI=10.1073/pnas.86.8.2804; PMCID=PMC287007

Knuth A., Wolfel T., Klehmann-Hieb E., Boon T., Meyer zum Buschenfelde K.-H.

Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.

Proc. Natl. Acad. Sci. U.S.A. 86:2804-2808(1989)