PANC1细胞

PANC-1、PANC-1、PANC-1细胞、PANC-1细胞、PANC-1人胰腺癌肿瘤细胞

Cell line name PANC-1

Synonyms Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P

Accession CVCL_0480

Resource Identification Initiative To cite this cell line use: PANC-1 (RRID:CVCL_0480)

Comments Part of: AKT genetic alteration cell panel (ATCC TCP-1029).

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: ENCODE project common cell types; tier 3.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: 21 +- 1.6 hours (PubMed=21515691); 25.83 +- 2.03 hours (PubMed=25394408); 25.8 +- 2.8 hours (PubMed=27067801); 52 hours (CLS=300228); ~42 hours (DSMZ=ACC-783); ~32 hours (PBCF); 15.02 hours (JWGray panel).

Karyotypic information: Has lost chromosome Y.

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: Metabolome analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: Proteome analysis by 2D-DE/MS.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).

Caution: Additional TP53 mutation in c.815T>C indicated incorrectly in PubMed=1630814.

Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.

PubMed=7961102; DOI=10.1111/j.1349-7006.1994.tb02898.x; PMCID=PMC5919355

Suwa H., Yoshimura T., Yamaguchi N., Kanehira K., Manabe T., Imamura M., Hiai H., Fukumoto M.

K-ras and p53 alterations in genomic DNA and transcripts of human pancreatic adenocarcinoma cell lines.

Jpn. J. Cancer Res. 85:1005-1014(1994)

 

PubMed=8026879; DOI=10.1002/ijc.2910580207

Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.

Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.

Int. J. Cancer 58:185-191(1994)

 

PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7

Simon B., Weinel R., Hohne M., Watz J., Schmidt J., Kortner G., Arnold R.

Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma.

Gastroenterology 106:1645-1651(1994)

 

PubMed=8286197; DOI=10.1038/bjc.1994.24; PMCID=PMC1968784

Lohr J.-M., Trautmann B., Gottler M., Peters S., Zauner I., Maillet B., Kloppel G.

Human ductal adenocarcinomas of the pancreas express extracellular matrix proteins.

Br. J. Cancer 69:144-151(1994)

 

PubMed=21607521; DOI=10.3892/or.1.6.1223

Iguchi H., Morita R., Yasuda D., Takayanagi R., Ikeda Y., Takada Y., Shimazoe T., Nawata H., Kono A.

Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.

Oncol. Rep. 1:1223-1227(1994)

 

PubMed=9023415; DOI=10.1006/cimm.1996.1062

Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.

HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.

Cell. Immunol. 175:101-110(1997)

 

PubMed=9788440; DOI=10.1038/sj.onc.1202118

Villanueva A., Garcia C., Paules Blazquez A.B., Vicente M., Megias M., Reyes G., de Villalonga P., Agell N., Lluis F., Bachs O., Capella G.

Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.

Oncogene 17:1969-1978(1998)

 

PubMed=10027410; DOI=10.1016/S0002-9440(10)65298-4; PMCID=PMC1850008

Ghadimi B.M., Schrock E., Walker R.L., Wangsa D., Jauho A., Meltzer P.S., Ried T.

Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.

Am. J. Pathol. 154:525-536(1999)

 

PubMed=11115575; DOI=10.3892/or.8.1.89

Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.

Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.

Oncol. Rep. 8:89-92(2001)

 

PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U

Wallrapp C., Hahnel S., Boeck W., Soder A., Mincheva A., Lichter P., Leder G., Gansauge F., Sorio C., Scarpa A., Gress T.M.

Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis.

Int. J. Cancer 91:340-344(2001)