436细胞

MDA-MB-436/MDA-MB-436细胞系/MDA-MB-436细胞株/MDA-MB-436 人乳腺癌细胞

Cell line name MDA-MB-436

Synonyms MDA_MB_436; MDA MB 436; MDA-Mb-436; MDA-MB436; MDAMB436; MDA-436; MDA436; MB436; MD Anderson-Metastatic Breast-436

Accession CVCL_0623

Resource Identification Initiative To cite this cell line use: MDA-MB-436 (RRID:CVCL_0623)

Comments Group: Triple negative breast cancer (TNBC) cell line.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: JWGray breast cancer cell line panel.

Part of: ICBP43 breast cancer cell line panel.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: 89.31 hours (JWGray panel).

Microsatellite instability: Instable (MSI-low) (Sanger).

Omics: Array-based CGH.

Omics: Chromatin accessibility by ATAC-seq.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Glycoproteome analysis by proteomics.

Omics: H2BK120ub ChIP-seq epigenome analysis.

Omics: H3K23ac ChIP-seq epigenome analysis.

Omics: H3K27ac ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K36me3 ChIP-seq epigenome analysis.

Omics: H3K4me1 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: H3K79me2 ChIP-seq epigenome analysis.

Omics: H3K9ac ChIP-seq epigenome analysis.

Omics: H3K9me3 ChIP-seq epigenome analysis.

Omics: H4K8ac ChIP-seq epigenome analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

DOI=10.1016/B978-0-12-333530-2.50009-5

Leibovitz A.

Cell lines from human breast.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

 

PubMed=9288768

Ahmadian M., Wistuba I.I., Fong K.M., Behrens C., Kodagoda D.R., Saboorian M.H., Shay J.W., Tomlinson G.E., Blum J.L., Minna J.D., Gazdar A.F.

Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.

Cancer Res. 57:3664-3668(1997)

 

PubMed=9823299

Khan J., Simon R.M., Bittner M., Chen Y.-D., Leighton S.B., Pohida T., Smith P.D., Jiang Y., Gooden G.C., Trent J.M., Meltzer P.S.

Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.

Cancer Res. 58:5009-5013(1998)

 

PubMed=10862037; DOI=10.1002/1098-2264(200007)28:3<308::AID-GCC9>3.0.CO;2-B

Kytola S., Rummukainen J., Nordgren A., Karhu R., Farnebo F., Isola J.J., Larsson C.

Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping.

Genes Chromosomes Cancer 28:308-317(2000)

 

PubMed=10969801

Forozan F., Mahlamaki E.H., Monni O., Chen Y.-D., Veldman R., Jiang Y., Gooden G.C., Ethier S.P., Kallioniemi A.H., Kallioniemi O.-P.

Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.

Cancer Res. 60:4519-4525(2000)

 

PubMed=11343771; DOI=10.1016/S0165-4608(00)00387-3

Rummukainen J., Kytola S., Karhu R., Farnebo F., Larsson C., Isola J.J.

Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping.

Cancer Genet. Cytogenet. 126:1-7(2001)

 

PubMed=15677628; DOI=10.1093/carcin/bgi032

Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.

Carcinogenesis 26:923-930(2005)

 

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853

Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M., van den Ouweland A.M.W., Merajver S.D., Ethier S.P., Schutte M.

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.

Cancer Res. 66:41-45(2006)

 

PubMed=16541312; DOI=10.1007/s10549-006-9186-z

Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.

Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.

Breast Cancer Res. Treat. 99:97-101(2006)

 

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521

Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.-L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Cancer Cell 10:515-527(2006)

 

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005

Kenny P.A., Lee G.Y., Myers C.A., Neve R.M., Semeiks J.R., Spellman P.T., Lorenz K., Lee E.H., Barcellos-Hoff M.H., Petersen O.W., Gray J.W., Bissell M.J.

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.

Mol. Oncol. 1:84-96(2007)

 

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084

Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J., Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D., Pollack J.R.

Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

PLoS ONE 4:E6146-E6146(2009)

 

DOI=10.25904/1912/1434

Morrison B.J.

Breast cancer stem cells: tumourspheres and implications for therapy.

Thesis PhD (2010); Griffith University; Brisbane; Australia

 

PubMed=19593635; DOI=10.1007/s10549-009-0460-8

Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F., Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J., Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M., Zwarthoff E.C., Teunisse A., van der Spek P.J., Klijn J.G.M., Dinjens W.N.M., Ethier S.P., Clevers H.C., Jochemsen A.G., den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.

Breast Cancer Res. Treat. 121:53-64(2010)

 

PubMed=21778573; DOI=10.3233/BD-2010-0307; PMCID=PMC3532890

Chavez K.J., Garimella S.V., Lipkowitz S.

Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer.

Breast Dis. 32:35-48(2010)