A375细胞

A-375】A-375细胞/A-375细胞/A-375人恶性黑色素瘤细胞Cell line name A-375

Synonyms A 375; A375; A375-MEL; A375-mel; A375mel; 375

Accession CVCL_0132

Resource Identification Initiative To cite this cell line use: A-375 (RRID:CVCL_0132)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: MD Anderson Cell Lines Project.

Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).

Population: Caucasian.

Doubling time: 26.9 +- 6.9 hours (PubMed=29275043); ~32 hours (PBCF).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep phosphoproteome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: Proteome analysis by 2D-DE/MS.

Omics: Secretome proteome analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: A-735; Note=Occasionally.

Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.

PubMed=4357758; DOI=10.1093/jnci/51.5.1417

Giard D.J., Aaronson S.A., Todaro G.J., Arnstein P., Kersey J.H., Dosik H., Parks W.P.

In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.

J. Natl. Cancer Inst. 51:1417-1423(1973)

 

PubMed=265522; DOI=10.1073/pnas.74.2.565; PMCID=PMC392331

Fabricant R.N., De Larco J.E., Todaro G.J.

Nerve growth factor receptors on human melanoma cells in culture.

Proc. Natl. Acad. Sci. U.S.A. 74:565-569(1977)

 

PubMed=327080; DOI=10.1093/jnci/59.1.221

Fogh J., Fogh J.M., Orfeo T.

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

J. Natl. Cancer Inst. 59:221-226(1977)

 

PubMed=833871; DOI=10.1093/jnci/58.2.209

Fogh J., Wright W.C., Loveless J.D.

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

J. Natl. Cancer Inst. 58:209-214(1977)

 

DOI=10.1007/BF00199208

Bruggen J., Sorg C., Macher E.

Membrane associated antigens of human malignant melanoma V: Serological typing of cell lines using antisera from nonhuman primates.

Cancer Immunol. Immunother. 5:53-62(1978)

 

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x

Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.

Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.

Tissue Antigens 11:279-286(1978)

 

PubMed=375235; DOI=10.1073/pnas.76.3.1288; PMCID=PMC383236

Sherwin S.A., Sliski A.H., Todaro G.J.

Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.

Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979)

 

PubMed=22282976; DOI=10.1093/carcin/1.1.21

Day R.S. 3rd, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Mattern M.R.

Human tumor cell strains defective in the repair of alkylation damage.

Carcinogenesis 1:21-32(1980)

 

DOI=10.1007/BF00205883

Bruggen J., Macher E., Sorg C.

Expression of surface antigens and its relation to parameters of malignancy in human malignant melanoma.

Cancer Immunol. Immunother. 10:121-127(1981)

 

PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157

Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A., Aaronson S.A., Wong-Staal F.

Differential expression of the amv gene in human hematopoietic cells.

Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982)

 

PubMed=6220172

Dracopoli N.C., Fogh J.

Polymorphic enzyme analysis of cultured human tumor cell lines.

J. Natl. Cancer Inst. 70:469-476(1983)

 

PubMed=6500159; DOI=10.1159/000163283

Gershwin M.E., Lentz D., Owens R.B.

Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.

Exp. Cell Biol. 52:361-370(1984)

 

PubMed=6584666; DOI=10.1093/jnci/72.4.913

Kozlowski J.M., Hart I.R., Fidler I.J., Hanna N.

A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice.

J. Natl. Cancer Inst. 72:913-917(1984)

 

PubMed=3518877; DOI=10.3109/07357908609038260

Fogh J.

Human tumor lines for cancer research.

Cancer Invest. 4:157-184(1986)

 

PubMed=1832891; DOI=10.1016/0277-5379(91)90277-K

Hansson J., Fichtinger-Schepman A.M.J., Edgren M.R., Ringborg U.

Comparative study of two human melanoma cell lines with different sensitivities to mustine and cisplatin.

Eur. J. Cancer 27:1039-1045(1991)

 

PubMed=9670966; DOI=10.4049/jimmunol.161.2.877

Bettinotti M.P., Kim C.J., Lee K.-H., Roden M., Cormier J.N., Panelli M.C., Parker K.K., Marincola F.M.

Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy.

J. Immunol. 161:877-889(1998)

 

PubMed=9973934; DOI=10.1016/S0165-4608(98)00122-8

Nelson M.A., Ariza M.E., Yang J.-M., Thompson F.H., Taetle R., Trent J.M., Wymer J., Massey-Brown K.S., Broome-Powell M., Easton J., Lahti J.M., Kidd V.J.

Abnormalities in the p34cdc2-related PITSLRE protein kinase gene complex (CDC2L) on chromosome band 1p36 in melanoma.

Cancer Genet. Cytogenet. 108:91-99(1999)

 

PubMed=10497214; DOI=10.1074/jbc.274.40.28505

Ariza M.E., Broome-Powell M., Lahti J.M., Kidd V.J., Nelson M.A.

Fas-induced apoptosis in human malignant melanoma cell lines is associated with the activation of the p34(cdc2)-related PITSLRE protein kinases.

J. Biol. Chem. 274:28505-28513(1999)

 

PubMed=12068308; DOI=10.1038/nature00766

Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Mutations of the BRAF gene in human cancer.

Nature 417:949-954(2002)

 

PubMed=14871852; DOI=10.1158/0008-5472.CAN-03-2209

Hogan K.T., Coppola M.A., Gatlin C.L., Thompson L.W., Shabanowitz J., Hunt D.F., Engelhard V.H., Ross M.M., Slingluff C.L. Jr.

Identification of novel and widely expressed cancer/testis gene isoforms that elicit spontaneous cytotoxic T-lymphocyte reactivity to melanoma.

Cancer Res. 64:1157-1163(2004)

 

PubMed=15009714; DOI=10.1046/j.0022-202X.2004.22243.x; PMCID=PMC2586668

Tsao H., Goel V., Wu H., Yang G., Haluska F.G.

Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.

J. Invest. Dermatol. 122:337-341(2004)

 

PubMed=15467732; DOI=10.1038/sj.onc.1208152

Tanami H., Imoto I., Hirasawa A., Yuki Y., Sonoda I., Inoue J., Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

Oncogene 23:8796-8804(2004)

 

PubMed=17308088; DOI=10.1158/0008-5472.CAN-06-3311

Shields J.M., Thomas N.E., Cregger M., Berger A.J., Leslie M., Torrice C., Hao H.-L., Penland S., Arbiser J.L., Scott G.A., Zhou T., Bar-Eli M., Bear J.E., Der C.J., Kaufmann W.K., Rimm D.L., Sharpless N.E.

Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.

Cancer Res. 67:1502-1512(2007)

 

PubMed=18172304; DOI=10.1158/0008-5472.CAN-07-1939

Sabatino M., Zhao Y.-D., Voiculescu S., Monaco A., Robbins P.F., Karai L., Nickoloff B.J., Maio M., Selleri S., Marincola F.M., Wang E.

Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesis.

Cancer Res. 68:122-131(2008)