BJ

BJ/BJ细胞系/BJ细胞株/BJ人皮肤成纤维细胞

Cell line name BJ [Human fibroblast]

Synonyms FF-WT-BJ; BJ1

Accession CVCL_3653

Resource Identification Initiative To cite this cell line use: BJ [Human fibroblast] (RRID:CVCL_3653)

Comments Part of: ENCODE project common cell types; tier 3.

Population: Caucasian.

Senescence: Senesces at 72 PDL. Has a long lifespan in comparison with other normal human fibroblast cell lines (ATCC=CRL-2522).

Omics: CTCF ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K36me3 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: DNA methylation analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.

Cell type: Fibroblast of foreskin; CL=CL_1001608.

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

PubMed=12554677; DOI=10.1093/hmg/ddg023

Tchirkov A., Lansdorp P.M.

Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia.

Hum. Mol. Genet. 12:227-232(2003)

 

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544

Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.

Dynamic DNA methylation across diverse human cell lines and tissues.

Genome Res. 23:555-567(2013)

 

PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037

Hofving T., Arvidsson Y., Almobarak B., Inge L., Pfragner R., Persson M., Stenman G., Kristiansson E., Johanson V., Nilsson O.

The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.

Endocr. Relat. Cancer 25:367-380(2018)