MHCC-97H高转移人肝癌细胞

Cell line name MHCC97-H

Synonyms MHCC 97-H; MHCC-97H; MHCC97H

Accession CVCL_4972

Resource Identification Initiative To cite this cell line use: MHCC97-H (RRID:CVCL_4972)

Comments Part of: Liver Cancer Model Repository (LIMORE).

Population: Chinese.

Characteristics: High metastatic potential.

Doubling time: 28.79 hours (PubMed=31378681).

Karyotypic information: Has lost chromosome Y.

Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).

Omics: Deep exome analysis.

Omics: Deep phosphoproteome analysis.

Omics: Genome sequenced.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

PubMed=11819844; DOI=10.3748/wjg.v7.i5.630; PMCID=PMC4695564

Li Y., Tang Z.-Y., Ye S.-L., Liu Y.-K., Chen J., Xue Q., Chen J., Gao D.-M., Bao W.-H.

Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97.

World J. Gastroenterol. 7:630-636(2001)

 

PubMed=15048980; DOI=10.1002/pmic.200300653

Ding S.-J., Li Y., Shao X.-X., Zhou H., Zeng R., Tang Z.-Y., Xia Q.-C.

Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials.

Proteomics 4:982-994(2004)

 

PubMed=15146329; DOI=10.1007/s00432-004-0564-9

Li Y., Tian B., Yang J., Zhao L., Wu X., Ye S.-L., Liu Y.-K., Tang Z.-Y.

Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics.

J. Cancer Res. Clin. Oncol. 130:460-468(2004)

 

PubMed=23505090; DOI=10.1002/hep.26402

Wang K., Lim H.Y., Shi S., Lee J., Deng S.-B., Xie T., Zhu Z., Wang Y.-L., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.-C.

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.

Hepatology 58:706-717(2013)

 

PubMed=25690035; DOI=10.3390/ijms16024209; PMCID=PMC4346953

Tian M.-M., Cheng H., Wang Z.-Q., Su N., Liu Z.-X., Sun C.-Q., Zhen B., Hong X.-C., Xue Y., Xu P.

Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H.

Int. J. Mol. Sci. 16:4209-4225(2015)

 

PubMed=25886575; DOI=10.1186/s12885-015-1166-4; PMCID=PMC4380258

Dang H., Steinway S.N., Ding W., Rountree C.B. Jr.

Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma.

BMC Cancer 15:161.1-161.11(2015)

 

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001

Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.

Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.

Gastroenterology 157:760-776(2019)

 

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724

Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.

A pharmacogenomic landscape in human liver cancers.

Cancer Cell 36:179-193.e11(2019)

 

PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008; PMCID=PMC7452459

Lin Y.-L., Li Y.

Study on the hepatocellular carcinoma model with metastasis.

Genes Dis. 7:336-350(2020)