MDA-MB-468人乳腺癌细胞

MDA-MB-468/MDA-MB-468细胞系/MDA-MB-468细胞株/MDA-MB-468人乳腺癌细胞

Cell line name MDA-MB-468

Synonyms MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468

Accession CVCL_0419

Resource Identification Initiative To cite this cell line use: MDA-MB-468 (RRID:CVCL_0419)

Comments Group: Triple negative breast cancer (TNBC) cell line.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: EGFR genetic alteration cell panel (ATCC TCP-1027).

Part of: JWGray breast cancer cell line panel.

Part of: ICBP43 breast cancer cell line panel.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: NCI-60 cancer cell line panel.

Population: African American.

Doubling time: 40.6 hours (PubMed=32576280); ~30-40 hours (DSMZ=ACC-738); 62 hours (NCI-DTP=MDA-MB-468); ~47 hours (PBCF); 79.76 hours (JWGray panel).

Microsatellite instability: Stable (MSS) (PubMed=15677628; Sanger).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Fluorescence phenotype profiling.

Omics: Genome sequenced.

Omics: Glycoproteome analysis by proteomics.

Omics: H2BK120ub ChIP-seq epigenome analysis.

Omics: H3K23ac ChIP-seq epigenome analysis.

Omics: H3K27ac ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K36me3 ChIP-seq epigenome analysis.

Omics: H3K4me1 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: H3K79me2 ChIP-seq epigenome analysis.

Omics: H3K9ac ChIP-seq epigenome analysis.

Omics: H3K9me3 ChIP-seq epigenome analysis.

Omics: H4K8ac ChIP-seq epigenome analysis.

Omics: lncRNA expression profiling.

Omics: Metabolome analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

PubMed=11414198; DOI=10.1007/s004320000207

Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

J. Cancer Res. Clin. Oncol. 127:375-386(2001)

 

PubMed=12353263; DOI=10.1002/gcc.10107

Popovici C., Basset C., Bertucci F., Orsetti B., Adelaide J., Mozziconacci M.-J., Conte N., Murati A., Ginestier C., Charafe-Jauffret E., Ethier S.P., Lafage-Pochitaloff M., Theillet C., Birnbaum D., Chaffanet M.

Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.

Genes Chromosomes Cancer 35:204-218(2002)

 

PubMed=12800145; DOI=10.1002/gcc.10218

Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B., Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A., Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D., Edwards P.A.W., Chaffanet M.

A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.

Genes Chromosomes Cancer 37:333-345(2003)

 

PubMed=15153330; DOI=10.1593/neo.3292; PMCID=PMC1502105

Watts G.S., Oshiro M.M., Junk D.J., Wozniak R.J., Watterson S.J., Domann F.E., Futscher B.W.

The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells.

Neoplasia 6:187-194(2004)

 

PubMed=15677628; DOI=10.1093/carcin/bgi032

Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.

Carcinogenesis 26:923-930(2005)

 

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853

Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M., van den Ouweland A.M.W., Merajver S.D., Ethier S.P., Schutte M.

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.

Cancer Res. 66:41-45(2006)

 

PubMed=16541312; DOI=10.1007/s10549-006-9186-z

Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.

Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.

Breast Cancer Res. Treat. 99:97-101(2006)

 

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521

Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.-L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Cancer Cell 10:515-527(2006)

 

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005

Kenny P.A., Lee G.Y., Myers C.A., Neve R.M., Semeiks J.R., Spellman P.T., Lorenz K., Lee E.H., Barcellos-Hoff M.H., Petersen O.W., Gray J.W., Bissell M.J.

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.

Mol. Oncol. 1:84-96(2007)

 

PubMed=18262045; DOI=10.1016/j.cancergencyto.2007.05.030

Xu J., Chambers A.F., Tuck A.B., Rodenhiser D.I.

Molecular cytogenetic characterization of human breast cancer cell line MDA-MB-468 and its variant 468LN, which displays aggressive lymphatic metastasis.

Cancer Genet. Cytogenet. 181:1-7(2008)

 

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084

Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J., Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D., Pollack J.R.

Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

PLoS ONE 4:E6146-E6146(2009)

 

DOI=10.25904/1912/1434

Morrison B.J.

Breast cancer stem cells: tumourspheres and implications for therapy.

Thesis PhD (2010); Griffith University; Brisbane; Australia

 

PubMed=19593635; DOI=10.1007/s10549-009-0460-8

Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F., Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J., Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M., Zwarthoff E.C., Teunisse A., van der Spek P.J., Klijn J.G.M., Dinjens W.N.M., Ethier S.P., Clevers H.C., Jochemsen A.G., den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.

Breast Cancer Res. Treat. 121:53-64(2010)

 

PubMed=20070913; DOI=10.1186/1471-2407-10-15; PMCID=PMC2836299

Tsuji K., Kawauchi S., Saito S., Furuya T., Ikemoto K., Nakao M., Yamamoto S., Oka M., Hirano T., Sasaki K.

Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: comparison of the CGH profiles between cancer cell lines and primary cancer tissues.

BMC Cancer 10:15.1-15.10(2010)