GH3

GH3/GH3细胞系/GH3细胞株/GH3大鼠垂体瘤细胞

Cell line name    GH3
Synonyms    GH 3
Accession    CVCL_0273
Resource Identification Initiative    To cite this cell line use: GH3 (RRID:CVCL_0273)
Comments    Doubling time: ~60-90 hours (DSMZ=ACC-469).
Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
Disease    Rat pituitary gland neoplasm (NCIt: C132194)
Species of origin    Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar Furth; RS=RS:0000982.
Hierarchy    Children:
CVCL_U370 (GH3/GH-EYFP)    CVCL_0274 (GH3B6)    CVCL_UJ46 (GH3C1)
CVCL_UJ47 (GH3C6)    CVCL_0276 (GH4C1)
Originate from same individual    CVCL_0610 ! GH1
Sex of cell    Female
Age at sampling    7M
Category    Cancer cell line
Publications    
PubMed=4951281; DOI=10.1210/endo-82-2-342
Tashjian A.H. Jr., Yasumura Y., Levine L., Sato G.H., Parker M.L.
Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone.
Endocrinology 82:342-352(1968)

PubMed=5513559; DOI=10.1083/jcb.47.1.61; PMCID=PMC2108385
Tashjian A.H. Jr., Bancroft F.C., Levine L.
Production of both prolactin and growth hormone by clonal strains of rat pituitary tumor cells. Differential effects of hydrocortisone and tissue extracts.
J. Cell Biol. 47:61-70(1970)

PubMed=4327442; DOI=10.1016/0006-291X(71)90644-9
Tashjian A.H. Jr., Barowsky N.J., Jensen D.K.
Thyrotropin releasing hormone: direct evidence for stimulation of prolactin production by pituitary cells in culture.
Biochem. Biophys. Res. Commun. 43:516-523(1971)

PubMed=218079; DOI=10.1016/S0076-6879(79)58167-1
Tashjian A.H. Jr.
Clonal strains of hormone-producing pituitary cells.
Methods Enzymol. 58:527-535(1979)

PubMed=15541569; DOI=10.1016/j.mce.2004.07.018
Ooi G.T., Tawadros N., Escalona R.M.
Pituitary cell lines and their endocrine applications.
Mol. Cell. Endocrinol. 228:1-21(2004)