hTERT-HPNE

hTERT-HPNE/hTERT-HPNE细胞系/hTERT-HPNE细胞株/hTERT-HPNE人正常胰腺导管细胞

Cell line name hTERT-HPNE

Synonyms hTERT-Human Pancreatic Nestin-Expressing cells

Accession CVCL_C466

Resource Identification Initiative To cite this cell line use: hTERT-HPNE (RRID:CVCL_C466)

Comments Doubling time: ~26 hours (PBCF).

Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11730; TERT.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.

Cell type: Pancreatic ductal cell; CL=CL_0002079.

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_C467 (hTERT-HPNE E6/E7)

Sex of cell Male

Age at sampling 52Y

Category Telomerase immortalized cell line

STR profile Source(s): ATCC=CRL-4023

 

Markers:

Amelogenin X,Y

CSF1PO 12

D2S1338 17,22

D3S1358 15

D5S818 11

D7S820 9,10

D8S1179 10,13

D13S317 12,13

D16S539 12,13

D18S51 13,16

D19S433 12,16.2

D21S11 30

FGA 23,24

Penta D 11

Penta E 7,10

TH01 8,9

TPOX 8,11

vWA 17

 

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PubMed=12589817; DOI=10.1016/S0006-291X(03)00086-X

Lee K.M., Nguyen C., Ulrich A.B., Pour P.M., Ouellette M.M.

Immortalization with telomerase of the Nestin-positive cells of the human pancreas.

Biochem. Biophys. Res. Commun. 301:1038-1044(2003)

 

PubMed=17332339; DOI=10.1158/0008-5472.CAN-06-3752

Campbell P.M., Groehler A.L., Lee K.M., Ouellette M.M., Khazak V., Der C.J.

K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.

Cancer Res. 67:2098-2106(2007)