LN229

LN-229/LN-229细胞系/LN-229细胞株/LN-229人脑髓母细胞瘤细胞

Cell line name LN-229

Synonyms LN 229; LN229; LNT-229

Accession CVCL_0393

Resource Identification Initiative To cite this cell line use: LN-229 (RRID:CVCL_0393)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Caucasian.

Doubling time: 24 hours (PubMed=9842975); 31 hours (PubMed=25984343).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Cell surface proteome.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: HLA class I peptidome analysis by proteomics.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: LN22; Cosmic=2580915.

Derived from site: In situ; Brain, right frontal parieto-occipital cortex.

DOI=10.1007/0-306-46861-1_11

Ali-Osman F.

Brain tumors.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

 

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x; PMCID=PMC8098486

Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.

Brain Pathol. 9:469-479(1999)

 

PubMed=14614447; DOI=10.1038/sj.onc.1207198

Wischhusen J., Naumann U., Ohgaki H., Rastinejad F., Weller M.

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.

Oncogene 22:8233-8245(2003)

 

PubMed=14655754; DOI=10.1111/j.1750-3639.2003.tb00479.x; PMCID=PMC8095903

Bahr O., Rieger J., Duffner F., Meyermann R., Weller M., Wick W.

P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.

Brain Pathol. 13:482-494(2003)

 

PubMed=16697959; DOI=10.1016/j.ccr.2006.03.030

Lee J., Kotliarova S., Kotliarov Y., Li A.-G., Su Q., Donin N.M., Pastorino S., Purow B.W., Christopher N., Zhang W., Park J.K., Fine H.A.

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

Cancer Cell 9:391-403(2006)

 

PubMed=17595512; DOI=10.1159/000104150

Rieger J., Frank B., Weller M., Wick W.

Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand.

Cell. Physiol. Biochem. 20:23-34(2007)

 

PubMed=19365568; DOI=10.1371/journal.pone.0005209; PMCID=PMC2666263

Bax D.A., Little S.E., Gaspar N., Perryman L., Marshall L., Viana-Pereira M., Jones T.A., Williams R.D., Grigoriadis A., Vassal G., Workman P., Sheer D., Reis R.M., Pearson A.D.J., Hargrave D., Jones C.

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.

PLoS ONE 4:E5209-E5209(2009)

 

PubMed=20504876; DOI=10.1093/neuonc/noq051; PMCID=PMC2940700

Berger B., Capper D., Lemke D., Pfenning P.-N., Platten M., Weller M., von Deimling A., Wick W., Weiler M.

Defective p53 antiangiogenic signaling in glioblastoma.

Neuro-oncol. 12:894-907(2010)

 

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112

Grzmil M., Morin P. Jr., Lino M.M., Merlo A., Frank S., Wang Y.-H., Moncayo G., Hemmings B.A.

MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.

Cancer Res. 71:2392-2402(2011)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)