KU812

KU812/KU812细胞系/KU812细胞株/KU812人外周血嗜碱性白血病细胞

Cell line name Ku812

Synonyms KU812; KU-812; KU.812; KU 812

Accession CVCL_0379

Resource Identification Initiative To cite this cell line use: Ku812 (RRID:CVCL_0379)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: LL-100 blood cancer cell line panel.

Population: Japanese.

Doubling time: 25 +- 2 hours (PubMed=11264164); ~20-30 hours (ATCC=CRL-2099); ~80-100 hours (DSMZ=ACC-378).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Cell type: Basophil progenitor cell; CL=CL_0000613.

PubMed=9644295; DOI=10.1159/000040837

Kaneko H., Horiike S., Sasai Y., Iwai T., Nakao M., Yokota S., Taniwaki M., Kashima K., Misawa S.-i.

Rare alteration of genomic structure or expression of the DPC4 gene in myelogenous leukemias.

Acta Haematol. 99:187-190(1998)

 

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Leuk. Res. 23:207-215(1999)

 

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.

Leuk. Res. 23:1055-1060(1999)

 

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

 

PubMed=11264164; DOI=10.1182/blood.V97.7.1999

Kano Y., Akutsu M., Tsunoda S., Mano H., Sato Y., Honma Y., Furukawa Y.

In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents.

Blood 97:1999-2007(2001)

 

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459

Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Short tandem repeat profiling provides an international reference standard for human cell lines.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

 

PubMed=15843827; DOI=10.1038/sj.leu.2403749

Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Leukemia 19:1042-1050(2005)

 

PubMed=16408098; DOI=10.1038/sj.leu.2404081

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Leukemia 20:471-476(2006)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=20809971; DOI=10.1186/1755-8166-3-15; PMCID=PMC2944125

Virgili A., Nacheva E.

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.

Mol. Cytogenet. 3:15.1-15.12(2010)