HK-2细胞

HK-2/HK-2细胞系/HK-2细胞株/HK-2人肾皮质近曲小管上皮细胞

Cell line name HK-2 [Human kidney]

Synonyms Hk-2; HK2; Human Kidney-2

Accession CVCL_0302

Resource Identification Initiative To cite this cell line use: HK-2 [Human kidney] (RRID:CVCL_0302)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Population: Caucasian.

Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.

Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.

Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.

Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).

Omics: SNP array analysis.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.

Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=20555413; DOI=10.1139/y10-023

Gunness P., Aleksa K., Kosuge K., Ito S., Koren G.

Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.

Can. J. Physiol. Pharmacol. 88:448-455(2010)

 

PubMed=22949125; DOI=10.1002/ijc.27822

Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.

Loss of PBRM1 expression is associated with renal cell carcinoma progression.

Int. J. Cancer 132:E11-E17(2013)

 

PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135

Sinha R., Winer A.G., Chevinsky M.S., Jakubowski C., Chen Y.-B., Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J.-D., Hakimi A.A.

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Nat. Commun. 8:15165.1-15165.10(2017)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)