U-87MG细胞

U-87 MG/U-87 MG/U-87 MG/人脑胶质母细胞瘤细胞

Cell line name U-87MG ATCC

Synonyms U-87MG; U-87 MG; U87 MG; U-87-MG; U87-MG; U87MG; U-87; U87; 87 MG; 87MG

Accession CVCL_0022

Resource Identification Initiative To cite this cell line use: U-87MG ATCC (RRID:CVCL_0022)

Comments Problematic cell line: Misidentified. This cell line is not the original glioblastoma cell line established in 1968 at the University of Uppsala. As described in PubMed=27582061 it is most probably also a glioblastoma cell line but whose origin is unknow. See U-87MG Uppsala (Cellosaurus=CVCL_GP63) for the original U-87MG cell line.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: ENCODE project common cell types; tier 3.

Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00535.

Population: Caucasian.

Doubling time: 39 hours (PubMed=9842975); 72 hours (PubMed=25984343); ~34 hours (PBCF).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Cell surface proteome.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep antibody staining analysis.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Genome sequenced.

Omics: HLA class I peptidome analysis by proteomics.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

PubMed=8069455; DOI=10.1007/BF02631450

Fukuchi K.-i., Hearn M.G., Deeb S.S., Smith A.C., Ngoc Thao D., Miyazaki J.-i., Bothwell M., Martin G.M.

Activity assays of nine heterogeneous promoters in neural and other cultured cells.

In Vitro Cell. Dev. Biol. Anim. 30:300-305(1994)

 

PubMed=9090379; DOI=10.1038/ng0497-356

Steck P.A., Pershouse M.A., Jasser S.A., Yung W.-K.A., Lin H., Ligon A.H., Langford L.A., Baumgard M.L., Hattier T., Davis T., Frye C., Hu R., Swedlund B., Teng D.H.-F., Tavtigian S.V.

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.

Nat. Genet. 15:356-362(1997)

 

PubMed=9230885; DOI=10.1093/jnci/89.14.1036

Gomez-Manzano C., Fueyo J., Kyritsis A.P., McDonnell T.J., Steck P.A., Levin V.A., Yung W.-K.A.

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.

J. Natl. Cancer Inst. 89:1036-1044(1997)

 

PubMed=9842975; DOI=10.1002/(SICI)1097-0215(19981218)79:6<640::AID-IJC15>3.0.CO;2-z

Weller M., Rieger J., Grimmel C., Van Meir E.G., De Tribolet N., Krajewski S., Reed J.C., von Deimling A., Dichgans J.

Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.

Int. J. Cancer 79:640-644(1998)

 

PubMed=10074188; DOI=10.1128/JVI.73.4.3338-3350.1999; PMCID=PMC104098

Arbour N., Cote G., Lachance C., Tardieu M., Cashman N.R., Talbot P.J.

Acute and persistent infection of human neural cell lines by human coronavirus OC43.

J. Virol. 73:3338-3350(1999)

 

PubMed=10402232; DOI=10.3892/ijo.15.2.237

Sharif T.R., Sharif M.

Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.

Int. J. Oncol. 15:237-243(1999)

 

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x; PMCID=PMC8098486

Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.

Brain Pathol. 9:469-479(1999)

 

PubMed=10560660; DOI=10.1097/00005072-199911000-00007

Schmidt E.E., Ichimura K., Goike H.M., Moshref A., Liu L., Collins V.P.

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

 

PubMed=11414198; DOI=10.1007/s004320000207

Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

J. Cancer Res. Clin. Oncol. 127:375-386(2001)