U251 MG细胞

U251细胞系、U251细胞株、U251神经胶质细胞瘤细胞、U251神经胶质细胞瘤细胞

Cell line name U-251MG

Synonyms U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6)

Accession CVCL_0021

Resource Identification Initiative To cite this cell line use: U-251MG (RRID:CVCL_0021)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: JFCR39 cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: NCI-60 cancer cell line panel.

Population: Caucasian.

Doubling time: 23 hours (PubMed=9842975); 24 hours (PubMed=25984343); 23.8 hours (NCI-DTP=U-251).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: Cell surface proteome.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep antibody staining analysis.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Fluorescence phenotype profiling.

Omics: lncRNA expression profiling.

Omics: Metabolome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.

PubMed=9220028; DOI=10.1016/S0303-7207(97)00080-4

Sharif T.R., Luo W., Sharif M.

Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway.

Mol. Cell. Endocrinol. 130:119-130(1997)

 

PubMed=9230885; DOI=10.1093/jnci/89.14.1036

Gomez-Manzano C., Fueyo J., Kyritsis A.P., McDonnell T.J., Steck P.A., Levin V.A., Yung W.-K.A.

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.

J. Natl. Cancer Inst. 89:1036-1044(1997)

 

PubMed=9614553; DOI=10.1038/sj.gt.3300605

Tada M., Sakuma S., Iggo R.D., Saya H., Sawamura Y., Fujiwara T., Roth J.A.

Monitoring adenoviral p53 transduction efficiency by yeast functional assay.

Gene Ther. 5:339-344(1998)

 

PubMed=9842975; DOI=10.1002/(SICI)1097-0215(19981218)79:6<640::AID-IJC15>3.0.CO;2-z

Weller M., Rieger J., Grimmel C., Van Meir E.G., De Tribolet N., Krajewski S., Reed J.C., von Deimling A., Dichgans J.

Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.

Int. J. Cancer 79:640-644(1998)

 

DOI=10.1007/0-306-46861-1_11

Ali-Osman F.

Brain tumors.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

 

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x; PMCID=PMC8098486

Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.

Brain Pathol. 9:469-479(1999)

 

PubMed=10551321; DOI=10.1111/j.1349-7006.1999.tb00838.x; PMCID=PMC5926156

Zhang S.-J., Endo S., Ichikawa T., Yoshimura J., Onda K., Tanaka R., Washiyama K., Kumanishi T.

Rare-type mutations of MMAC1 tumor suppressor gene in human glioma cell lines and their tumors of origin.

Jpn. J. Cancer Res. 90:934-941(1999)

 

PubMed=10560660; DOI=10.1097/00005072-199911000-00007

Schmidt E.E., Ichimura K., Goike H.M., Moshref A., Liu L., Collins V.P.

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

 

PubMed=10700174; DOI=10.1038/73432

Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T., Iyer V.R., Jeffrey S.S., van de Rijn M., Waltham M.C., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O.

Systematic variation in gene expression patterns in human cancer cell lines.

Nat. Genet. 24:227-235(2000)

 

PubMed=14614447; DOI=10.1038/sj.onc.1207198

Wischhusen J., Naumann U., Ohgaki H., Rastinejad F., Weller M.

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.

Oncogene 22:8233-8245(2003)

 

PubMed=14655754; DOI=10.1111/j.1750-3639.2003.tb00479.x; PMCID=PMC8095903

Bahr O., Rieger J., Duffner F., Meyermann R., Weller M., Wick W.

P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.

Brain Pathol. 13:482-494(2003)

 

PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742

Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L., Morse H.C. 3rd, Stroncek D., Marincola F.M.

HLA class I and II genotype of the NCI-60 cell lines.

J. Transl. Med. 3:11.1-11.8(2005)

 

PubMed=15900046; DOI=10.1093/jnci/dji133

Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y., Tomoda H., Yamori T., Tsuruo T.

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

J. Natl. Cancer Inst. 97:765-777(2005)

 

PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x; PMCID=PMC11159392

Saigusa K., Hashimoto N., Tsuda H., Yokoi S., Maruno M., Yoshimine T., Aoyagi M., Ohno K., Imoto I., Inazawa J.

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Cancer Sci. 96:676-683(2005)