H4细胞

H4/H4细胞系/H4细胞株/H4人脑神经胶质细胞瘤/星形细胞瘤

Cell line name H4

Synonyms H-4

Accession CVCL_1239

Resource Identification Initiative To cite this cell line use: H4 (RRID:CVCL_1239)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).

Part of: TCGA-110-CL cell line panel.

Population: Caucasian.

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Miscellaneous: Originally classified as originating from a neuroglioma, an obsolete classification. This cell line has been reclassified as an astrocytoma.

Derived from site: In situ; Brain; UBERON=UBERON_0000955.

PubMed=10074188; DOI=10.1128/JVI.73.4.3338-3350.1999; PMCID=PMC104098

Arbour N., Cote G., Lachance C., Tardieu M., Cashman N.R., Talbot P.J.

Acute and persistent infection of human neural cell lines by human coronavirus OC43.

J. Virol. 73:3338-3350(1999)

 

PubMed=10560660; DOI=10.1097/00005072-199911000-00007

Schmidt E.E., Ichimura K., Goike H.M., Moshref A., Liu L., Collins V.P.

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

 

PubMed=11414198; DOI=10.1007/s004320000207

Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

J. Cancer Res. Clin. Oncol. 127:375-386(2001)

 

PubMed=11508811; DOI=10.1023/A:1010680920087

Krex D., Mohr B., Hauses M., Ehninger G., Schackert H.K., Schackert G.

Identification of uncommon chromosomal aberrations in the neuroglioma cell line H4 by spectral karyotyping.

J. Neurooncol. 52:119-128(2001)

 

PubMed=19435942; DOI=10.1215/15228517-2009-025; PMCID=PMC2743214

Ichimura K., Pearson D.M., Kocialkowski S., Backlund L.M., Chan R., Jones D.T.W., Collins V.P.

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.

Neuro-oncol. 11:341-347(2009)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)