GSK3B抗体;GSK3B Polyclonal Antib

Description Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3a and Ser9 of GSK-3 References 1. EMBO J. 1998 Mar 2;17(5):1371-84. 2. Curr Biol. 2001 Jan 9;11(1):44-9. 3. Cancer Lett. 2003 Sep 25;199(2):201-8. Specification Aliases:GSK-3β; GSK3-beta Entrez GeneID:2932 Swissprot:P49841 clone:3D10 WB Predicted band size:46kDa Host/Isotype:Mouse IgG2a Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Mouse,Monkey,Rat Immunogen:Purified recombinant fragment of human GSK3B expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000