NOTCH3抗体;NOTCH3 Polyclonal Ant

Description This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). References 1.Cancer Res. 2014 Jun 15;74(12):3282-93. 2.PLoS One. 2013 Dec 18;8(12):e84659. Specification Aliases:IMF2; CASIL; CADASIL Entrez GeneID:4854 Swissprot:Q9UM47 clone:2E4D11 WB Predicted band size:243.6kDa Host/Isotype:Mouse IgG2b Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human Notch3 (AA: 47-156) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ELISA:1/10000