PRKAG1抗体;PRKAG1 Polyclonal Ant

Description The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. References 1. Circ Res. 2012 Aug 31;111(6):800-14. 2. Circ Res. 2012 Apr 27;110(9):1192-201. Specification Aliases:AMPKG Entrez GeneID:5571 Swissprot:P54619 clone:7H3E9 WB Predicted band size:37.6kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human PRKAG1 (AA: 230-331) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide. Application IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000