- ￥600 - 3200
- 上海莼试
- CS-01Y74197
- 国产
- 2025年11月05日
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- 详细信息
- 技术资料
- 库存：
29
- 英文名：
Cinnarizine
- CAS号：
298-57-7
- 供应商：
上海莼试
- 保存条件：
Store at -20°C
- 规格：
100mg 500mg
使用方法：
1.本蛋白酶抑制剂混合物为100×的储存液，使用时按照1:100的比例加入到裂解液中(例如，1ml裂解液中加入10μl蛋白酶抑制剂混合物)，混匀后即可使用。根据需要，0.5M的EDTA也按照1:100的比例加入到裂解液中（如用于检测金属蛋白酶活性，则不宜添加EDTA）。含有蛋白酶抑制剂混合物的裂解液宜现用现配，不宜配制后冻存待后续使用。
2. 待所需的抑制剂添加完毕混匀后，就可以开始进行哺乳动物组织的裂解和蛋白提取。
商品属性：
产品描述：
分子式:C26H28N2
分子量:368.51
溶解度:DMF: 14 mg/ml,DMF:PBS(pH7.2) (1:2): 0.3 mg/mol,DMSO: 2 mg/ml,Ethanol: 3 mg/ml
储存条件:Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
Cinnarizine is a calcium channel blocker.Blockers of calcium channel are drugs disrupting the calcium movement via calcium channels, which are usually used as antihypertensive therapies to decrease blood pressure in hypertension patients.In vitro: Previous study found that cinnarizine could inhibit the phosphorylation of both arterial myosin P-light chain and arterial actomyosin superprecipitation. Moreover, the concomitant inhibition of arterial superprecipitation and phosphorylation by perhexiline and cinnarizine was found to be similar to that of W-7. Such inhibitary effect was then characterized by a rightward shift in the pCa superprecipitation, depressed maximum activity as well as attenuation by exogenous calmodulin [1].In vivo: Previous animal study showed that augmented effects were obtained in MES seizure model when cinnarizine was combined with sodium valproate. Whereas, in PTZ-induced seizures, augmented effects were obtained when nifedipine was combined with sodium valproate [2].Clinical trial: The anti-vertigo effect of cinnarizine was evaluated in a double blinded, controlled study on fourty patients with well characterized peripheral or central vestibular disorders. Electronystagmography results did not show obviously detectable differences between patients treated with cinnarizine and placebo, and only a temporary depressant effect on vestibular nystagmus was orved in five healthy volunteers when cinnarizine dose was increased to 150 mg. In addition, cinnarizine was found to be generally well tolerated [3].
注意事项：
抗逆滴加序列
每次向板内滴加抗原时，移液器滴头要与平面45度悬空，不要触碰到孔内的液体，由后向前依次滴加(即浓度由低往高滴加)。
抗感染反应期
抗原抗体在室温20~25℃下，必须反应30min以上，若环境温度低于室温，可将微量反应板置于恒温培养箱中，使二者充分反应。
旅游温度
磷酸盐缓冲液的pH值要在高压灭菌后进行滴定，往往在高压后pH值会有所改变，所以高压后再调一次pH值更为准确。磷酸盐缓冲液一经使用保存期不要超过3周。当pH<5.8时，红细胞会产生自凝现象;当pH>7.8时，图形洗脱加快，易造成肉眼观察产生误差;p H=7.2时，红细胞沉降最充分，图形最清晰。
当滴注 1%红细胞悬液时，应经常摇晃红细胞悬液，使红细胞均匀地分布在磷酸缓冲液中，以防止红细胞下降。
反应时间及温度
加入鸡红血球之后，反应板在室温(20~25℃)静置30~40min，对照孔血球下沉于孔底，即可判定结果。若室温达不到实验要求，需相应调整反应时间。当环境温度低于4℃时，红细胞发生自凝;高于37℃时，会发生反应物分离和红细胞溶血。
公司正在出售的产品：
1.本蛋白酶抑制剂混合物为100×的储存液，使用时按照1:100的比例加入到裂解液中(例如，1ml裂解液中加入10μl蛋白酶抑制剂混合物)，混匀后即可使用。根据需要，0.5M的EDTA也按照1:100的比例加入到裂解液中（如用于检测金属蛋白酶活性，则不宜添加EDTA）。含有蛋白酶抑制剂混合物的裂解液宜现用现配，不宜配制后冻存待后续使用。
2. 待所需的抑制剂添加完毕混匀后，就可以开始进行哺乳动物组织的裂解和蛋白提取。
商品属性：
| 货号 | CS-01Y74197 | 规格 | 100mg 500mg |
| CAS号 | 298-57-7 | 分子量 | 368.51 |
| 含量 | >98.00% | 别名 | |
| 分子式 | C26H28N2 | 化学名 | |
| 产地 | 国产 | 用途 | 仅供科研研究实验 |
分子式:C26H28N2
分子量:368.51
溶解度:DMF: 14 mg/ml,DMF:PBS(pH7.2) (1:2): 0.3 mg/mol,DMSO: 2 mg/ml,Ethanol: 3 mg/ml
储存条件:Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
Cinnarizine is a calcium channel blocker.Blockers of calcium channel are drugs disrupting the calcium movement via calcium channels, which are usually used as antihypertensive therapies to decrease blood pressure in hypertension patients.In vitro: Previous study found that cinnarizine could inhibit the phosphorylation of both arterial myosin P-light chain and arterial actomyosin superprecipitation. Moreover, the concomitant inhibition of arterial superprecipitation and phosphorylation by perhexiline and cinnarizine was found to be similar to that of W-7. Such inhibitary effect was then characterized by a rightward shift in the pCa superprecipitation, depressed maximum activity as well as attenuation by exogenous calmodulin [1].In vivo: Previous animal study showed that augmented effects were obtained in MES seizure model when cinnarizine was combined with sodium valproate. Whereas, in PTZ-induced seizures, augmented effects were obtained when nifedipine was combined with sodium valproate [2].Clinical trial: The anti-vertigo effect of cinnarizine was evaluated in a double blinded, controlled study on fourty patients with well characterized peripheral or central vestibular disorders. Electronystagmography results did not show obviously detectable differences between patients treated with cinnarizine and placebo, and only a temporary depressant effect on vestibular nystagmus was orved in five healthy volunteers when cinnarizine dose was increased to 150 mg. In addition, cinnarizine was found to be generally well tolerated [3].
注意事项：
抗逆滴加序列
每次向板内滴加抗原时，移液器滴头要与平面45度悬空，不要触碰到孔内的液体，由后向前依次滴加(即浓度由低往高滴加)。
抗感染反应期
抗原抗体在室温20~25℃下，必须反应30min以上，若环境温度低于室温，可将微量反应板置于恒温培养箱中，使二者充分反应。
旅游温度
磷酸盐缓冲液的pH值要在高压灭菌后进行滴定，往往在高压后pH值会有所改变，所以高压后再调一次pH值更为准确。磷酸盐缓冲液一经使用保存期不要超过3周。当pH<5.8时，红细胞会产生自凝现象;当pH>7.8时，图形洗脱加快，易造成肉眼观察产生误差;p H=7.2时，红细胞沉降最充分，图形最清晰。
当滴注 1%红细胞悬液时，应经常摇晃红细胞悬液，使红细胞均匀地分布在磷酸缓冲液中，以防止红细胞下降。
反应时间及温度
加入鸡红血球之后，反应板在室温(20~25℃)静置30~40min，对照孔血球下沉于孔底，即可判定结果。若室温达不到实验要求，需相应调整反应时间。当环境温度低于4℃时，红细胞发生自凝;高于37℃时，会发生反应物分离和红细胞溶血。
公司正在出售的产品：
| Recombnant Human BMPR2, N-H | Pyrazinamide-BSA |
| Recombinant Human MIC19 | Recombinant Human TGFBR1, N-His |
| BP Antibody Blocking Peptide | Recombinant Human MSMB protein |
| DNTT Antibody Blocking Peptide | Recombinant Human BCR/ABL Protein, N-His & N-SUMO |
| CD8B Antibody Blocking Peptide | Recombinant Human FKBP1B, N-His |
| GLTPD2 Antibody Blocking Peptide | Recombinant Human CKAP4, N-His |
| KRBA1 Antibody Blocking Peptide | Recombinant Human HIF1A, N-His |
| Fe65 Protein Antibody Blocking Peptide | 细胞外基质蛋白FREM2封闭多肽 |
| PXYLP1 Antibody Blocking Peptide | Recombinant Human PKP1, N-GST |
| Plzf Antibody Blocking Peptide | Recombinant Human DSG3, C-His |
| ZZZ3 Antibody Blocking Peptide | Recombinant Human RPLP0 protein ,C- His Tag |
| KARS1 Antibody Blocking Peptide | Recombinant Escherichia phage RB14 uvsX protein ,N-His Tag |
| MBLAC2 Antibody Blocking Peptide | CinnarizineRecombinant Human AMBP protein |
| RTKN Antibody Blocking Peptide | Recombinant Human SDF4 protein |
| IKZF3 Antibody Blocking Peptide | Recombinant Human CD331/FGFR1, N-His |
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Cinnarizine
￥600 - 3200
