TGFβ2/ TGFB2, Human, Recombinant

TGFβ2/ TGFB2, Human, Recombina

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  • ¥1780 - 27980
  • Procell
  • PCK092
  • 武汉
  • 2025年07月12日
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    • 详细信息
    • 技术资料
    • 供应商

      武汉益普生物科技有限公司

    • 英文名

      TGFβ2/ TGFB2, Human, Recombinant

    • 规格

      10μg/50ug/500ug/1mg

    规格:10μg产品价格:¥1780.0
    规格:50ug产品价格:¥4980.0
    规格:500ug产品价格:¥17480.0
    规格:1mg产品价格:¥27980.0

    产品信息

    别名Transforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP
    物种Human
    表达宿主Human Cells
    序列信息Ala301-Ser412(Tyr340Phe)
    检索号P10600
    分子量12.7 KDa
    表观分子量12-14 KDa
    生物活性Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells. The ED50 for this effect is 10-80 pg/ml.

     

    产品特性

    纯度>95% as determined by reducing SDS-PAGE.
    内毒素<1.0 EU per µg as determined by LAL test.
    保存Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输Ambient temperature or ice pack.
    制剂Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5.
    复融Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

     

    背景介绍

    Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.

    TGFβ2/ TGFB2, Human, Recombina

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