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- 文献和实验
- 技术资料
- 亚型:
IgG2a, kappa
- 形态:
Liquid
- 保存条件:
at-20℃
- 适应物种:
Human
- 库存:
99
- 宿主:
Mouse
- 应用范围:
ELISA
- 浓度:
见说明
- 抗体英文名:
Anti-Human GARS1/Glycyl-tRNA synthetase Monoclonal antibody (SAA1935)
- 规格:
50-100ug
小鼠抗人GARS1/Glycyl-tRNA synthetase单克隆抗体(克隆号SAA1935)上海圻明生物优势供应欢迎咨询。配对抗体小课堂:
Paired antibodies are two antibodies that can bind to an antigenic molecule at the same time. Specifically:
Paired antibodies are commonly used in sandwich ELISA experiments
An antigenic molecule usually has multiple epitopes, and different antibodies can target different epitopes
When two antibodies are able to bind to different epitopes of the same antigenic molecule at the same time, the two antibodies are called paired antibodies
However, not all antibodies against different epitopes can be paired antibodies. Sometimes, when an antibody binds to an antigen, it may cause the configuration of other binding sites to change, making it impossible for other antibodies to bind properly
Steric hindrance effects may also result in two antibodies with close binding sites not being able to bind to the antigen at the same time
Therefore, the preparation of paired antibodies usually requires two steps: first the antibody is prepared, and then the paired antibody is screened
Screening of paired antibodies is typically performed using a sandwich ELISA method of bispecific antibodies, in which different combinations of antibodies are tested to determine which antibodies can be successfully paired
Paired antibodies have important applications in immunology research and diagnostics, especially in assays that require high specificity and sensitivity.

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文献和实验文献速递|Cell 封面:应激颗粒异常互作介导 CMT2 周围神经病变的共同机制
Impairs RNP Granule Function. Neuron, 2015. 88(4): p. 678-90. Motley, W.W., K. Talbot and K.H. Fischbeck, GARS axonopathy: not every neuron's cup of tRNA. 2010. 33(2): p. 59-66. Antonellis, A., et al., Functional analyses of glycyl-tRNA
应用案例 | Cell 封面文章发文,揭示无膜细胞器异常导致周围神经病的关键机制
-66. [9]. Antonellis, A., et al., Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons. J Neurosci, 2006. 26(41): p. 10397-406. [10]. Nangle, L.A., et al., Charcot-Marie-Tooth disease
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
), mRNA 502 NM_001537 Homo sapiens heat shock factor binding protein 1 (HSBP1), mRNA 874 NM_003680 Homo sapiens tyrosyl-tRNA synthetase (YARS), mRNA 535 NM_003345 Homo sapiens ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (UBE2I), mRNA
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