smartox离子通道研究用多肽毒素

 

Smartox Biotechnology是全球唯一一家专门生产动物毒液多肽毒素，用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

ADWX-1 

 

K_v1.3 channel blocker(钾离子通道K_v1.3阻断剂)

 

ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block voltage-gated mK_v1.3 channel with a high affinity (IC₅₀ = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ).ADWX-1 inhibits CD4⁺ CCR7^- T-cell proliferation. ADWX-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of K_v1.3 channel and auto-immunity pathways. 
 

ADWX-1 技术资料

氨基酸序列：

Val-Gly-Ile-Asn-Val-Lys-Cys⁷-Lys-His-Ser-Arg-Gln-Cys¹³-Leu-Lys-Pro-Cys¹⁷-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys²⁷-Thr-Asn-Gly-Lys-Cys³²-His-Cys³⁴-Thr-Pro-Lys-OH

二硫键：Cys⁷-Cys²⁷, Cys¹³-Cys³², Cys¹⁷-Cys³⁴ 

长度 (aa)：  37

分子式：C₁₆₉H₂₈₁N₅₇O₄₆S₇   

分子量： 4071.90 Da 

外观： White lyophilized solid

可溶性： water and saline buffer

CAS 号：not available

来源： Synthetic

纯度： > 98%

Agitoxin-2 

Blocker of K_v1.1 and K_v1.3 channels

钾离子通道K_v1.1 和K_v1.3阻断剂

Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated K_v1.3 and K_v1.1 channels. Agitoxin-2 inhibits K_v1.3 with an IC₅₀ value of around 200 pM and K_v1.1 with an IC₅₀ value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.

Agitoxin-2 技术资料

氨基酸序列：

 Gly-Val-Pro-Ile-Asn-Val-Ser-Cys⁸-Thr-Gly-Ser-Pro-Gln-Cys¹⁴-Ile-Lys-Pro-Cys¹⁸-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys²⁸-Met-Asn-Arg-Lys-Cys³³-His-Cys³⁵-Thr-Pro-Lys-OH

二硫键：Cys⁸-Cys²⁸; Cys¹⁴-Cys³³; Cys¹⁸-Cys³⁵ 

长度 (aa)：  38

分子式： C₁₆₉H₂₇₈N₅₄O₄₈S₈ 

分子量：4090.89 Da

外观： White lyophilized solid

可溶性：water and saline buffer

CAS 号： 168147-41-9

来源： Synthetic 

纯度： > 97 %

产品信息

13AGI002-00100	Agitoxin 2	0.1mg
13AGI002-00500	Agitoxin 2	0.5mg
13AGI002-01000	Agitoxin 2	1mg