- ￥900
- AAB
- 上海
- A17451
- 2025年09月25日
- WB,IHC-p,ELISA
- Rabbit
- Human,Mouse,Rat
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- 详细信息
- 技术资料
- 免疫原：
The antiserum was produced against synthesized peptide derived from human MDM4. AA range:336-385
- 形态：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 保存条件：
-20°C/1 year
- 克隆性：
Polyclonal
- 适应物种：
Human,Mouse,Rat
- 保质期：
1年
- 宿主：
Rabbit
- 应用范围：
WB,IHC-p,ELISA
- 浓度：
1 mg/ml
- 靶点：
MDM4
- 抗体英文名：
MDMX rabbit pAb
- 抗体名：
Protein Mdm4
- 规格：
50ul
MDM4, p53 regulator(MDM4) Homo sapiens This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011],
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MDMX rabbit pAb
￥900
