WEE1-IN-7,2924006-98-2

WEE1-IN-7 产品活性：WEE1-IN-7 (compound 12h) 是一种有效的具有口服活性的 WEE1 抑制剂，其IC50值为 2.1 nM。WEE1-IN-7 诱导细胞凋亡 (apoptosis) 和细胞周期停滞于 S 期。WEE1-IN-7 具有抗肿瘤活性。 产品来源： www.medchemexpress.cn/wee1-in-7.html 研究领域：Cell Cycle/DNA Damage | Apoptosis 作用靶点：Wee1 | Apoptosis In Vitro: WEE1-IN-7 (compound 12h) inhibits cell viability with IC50 values of 84, 82 nM for A427, Lovo cells, respectively. WEE1-IN-7 (0-800 nM; 48 h) induces apoptosis and cell cycle arrest at S phase in a dose-dependent manner. In Vivo: WEE1-IN-7 (60 mg/kg; p.o.; daily for 27 days) shows antitumor activity with the tumor growth inhibition (TGI) of 88% in Lovo CDX xenograft mice model. Pharmacokinetic Parameters. Admin. AUC (h·ng/mL) T1/2 (h) Vd (L/kg) CL (L/h/kg) Cmax F (%) intravenous (1 mg/kg) 118 1.06 11.3 8.20 - - intragastric (60 mg/kg) 4342 5.94 - - 498 61.64 相关产品：MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | Paclitaxel | LY294002 | Z-VAD-FMK | 2-Deoxy-D-glucose | Acetylcysteine | Angiotensin II human | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Oxaliplatin | Deferoxamine mesylate | Trametinib | Sorafenib | Gemcitabine | Temozolomide | Etoposide | Rotenone | Decitabine | Mdivi-1 | Monomethyl auristatin E | Ruxolitinib | Elesclomol | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。