Sodium metatungstate聚钨酸钠水合物,31

Sodium metatungstate hydrate 产品活性：Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate 是 NTPDase 抑制剂，NTPDase 1 (CD39)、NTPDase 3 和 NTPDase 2 的 Ki 的值分别为 2.58 μM、3.26 μM 和 28.8 μM。Sodium metatungstate hydrate 具有抗炎和抗癌作用。Sodium metatungstate hydrate 抑制 ATP 分解，但也阻断中枢突触传递。 产品来源： www.medchemexpress.cn/sodium-metatungstate-hydrate.html 研究领域：Immunology/Inflammation | Apoptosis 作用靶点：NTPDase | Pyroptosis In Vitro: Sodium metatungstate hydrate (100 μM, 15 min) inhibits the ATP-induced uptake of anionic dyes and the large ATP-induced channels in macrophage. Sodium metatungstate hydrate (100 μM, 8 h) inhibits ATP-induced P2X7-associated pyroptosis in macrophage. Sodium metatungstate hydrate (100 μM, 8-24 h) has a potent anti-inflammatory effect on macrophages. In Vivo: Sodium metatungstate hydrate (5 mg/kg, Intraperitoneal injection, single dose) shows different cytokine/chemokine responses in the peritoneum and systemically in the bloodstream in CD39 knockout mice. Sodium metatungstate hydrate (5 mg/kg, Intraperitoneal injection, once per day from 0 to day 4, day 7-11, and day 14-18.) combine with anti-CD73 antibody and AZD4635(HY-101980) reduces tumor load in multiple myeloma (MM) mice. 相关产品：Cisplatin | Disulfiram | 2-Bromohexadecanoic acid | LDC7559 | Sodium metatungstate | Polyphyllin VI | Ac-FLTD-CMK | NLRP3/AIM2-IN-3 | Ethyl pyruvate | ARL67156 trisodium | Punicalin | Triclabendazole | Morroniside | (-)-Aspartic acid | Nigericin | Ac-FEID-CMK TFA | Pep19-2.5 | PSB-06126 | PSB069 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | Antcin A | Antitumor agent-143 | Azalamellarin N | BTK-IN-15 | Caspase-3 activator 1 | D359-0396 | Disulfiram (Standard) 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。