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- HY-P10495
- 2025年12月05日
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文献和实验Elucidating Agonist-Selective Mechanisms of G Protein-Coupled Receptor Desensitization
to agonist-dependent regulation. In the case of the μ-opioid receptor (MOPr), we have shown that two agonists, morphine and the peptide agonist DAMGO, can induce MOPr desensitization by different mechanisms involving largely protein kinase C
Characterization of Nuclear Receptor Ligands by Multiplexed Peptide Interactions
a method to evaluate the effect that small molecules have on the binding interactions of a nuclear receptor protein with a series of peptides. The multiplexed microsphere?based system employs peptide?coupled microsphere populations that are fluorescently
Identification of Adipokine Receptor Agonists and Turning Them to Antagonists
selectivity of 1,000 in cellular assays. The design process of ObR antagonists included shortening of the peptide length and incorporating additional nonnatural residues. Here I take a look into this receptor agonist and antagonist discovery
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