SKL2001 (GMP),909089-13-0

SKL2001 (GMP) 产品活性：SKL2001 (GMP) 是 GMP 级别的 SKL2001 (HY-101085)。SKL2001 是 Wnt/β-catenin 信号通路的激动剂，具有抗肿瘤活性。SKL2001 通过破坏 Axin/β-catenin 相互作用，稳定细胞内 β-catenin。 产品来源： www.medchemexpress.cn/skl2001-gmp.html 研究领域：Stem Cell/Wnt 作用靶点：Wnt | β-catenin In Vitro: SKL2001 is an agonist of the Wnt/β-catenin pathway, and also upregulates the expression of Axin2, a downstream target of the Wnt/β-catenin pathway, but shows no effect on NF-κB, p53 reporter activity and GSK-3β activity. SKL2001 causes osteoblast differentiation (20 and 40 μM) and suppresses preadipocyte differentiation (5, 10, and 30 μM) via the activation of the Wnt/β-catenin pathway. SKL2001 (5, 10, and 30 μM) stabilizes intracellular β-catenin in 3T3-L1 cells. SKL2001 (40 μM) significantly inhibits the proliferation of HCT116 spheroids independently of cytotoxicity and the inhibition is reversible; SKL2001 cuases cell cycle arrest in HCT116 spheroids. SKL2001 (40 μM) enhances round-shape spheroid formation and E-cadherin expression. 相关产品：Laduviglusib | XAV-939 | IWR-1 | IWP-2 | Monensin sodium | ICG-001 | MSAB | Wnt-C59 | SKL2001 | Heparan Sulfate | Adavivint | Echinacoside | Wogonin | Pentagalloylglucose | Pyrvinium pamoate | Salinomycin sodium salt | BML-284 | LF3 | Tegatrabetan | NCB-0846 | iCRT3 | Ginkgetin | Toxoflavin | Foxy-5 TFA | FH535 | Box5 TFA | Cardamonin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。