CL-242817,86709-48-0

CL-242817 产品活性：CL-242817 是一种口服有效的血管紧张素转换酶 (ACE) 抑制剂。CL-242817 抑制血管紧张素 I 转换为血管紧张素 II 的过程，有降低血压的活性。CL-242817 还能改善 Monocrotaline (HY-N0750) 引起的肺损伤。CL-242817 可用于肺纤维化和高血压相关疾病的研究。 产品来源： www.medchemexpress.cn/cl-242817.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Angiotensin-converting Enzyme (ACE) In Vitro: CL-242817 effectively inhibits rabbit lung ACE in vitro (IC50=54.9 nM), angiotensin I (Al) induced contraction of isolated guinea pig ileum (IC50=0.82 pM), and enhances bradykinin (BK) induced contraction of isolated guinea pig ileum (EC50=0.383 pM). In Vivo: CL-242817 (60 mg/kg, p.o., everyday for six weeks) causes male Wistar rats to fail to gain weight at a normal rate and significantly reduces cardiac function, significantly improves vascular occlusion and monocholinergic injury caused by Monocrotaline (HY-N0750), inhibits ACE activity and reduces hydroxyproline (HP) content in the lungs. 相关产品：Ursodeoxycholic acid | Captopril | Talfirastide | MLN-4760 | (Z)-Guggulsterone | Enalapril maleate | Diminazene aceturate | Ramipril | Lisinopril dihydrate | Sinapinic acid | BMS-265246 | Peimisine | Alamandine | Perindopril erbumine | Benazepril hydrochloride | Plantainoside D | Enalaprilat dihydrate | Fosinopril sodium | Resorcinolnaphthalein | Omapatrilat | Mca-Ala-Pro-Lys(Dnp)-OH | Phosphoramidon Disodium | Temocapril hydrochloride | Trandolapril | Abz-FR-K(Dnp)-P-OH | Zofenopril calcium | Alacepril | Deserpidine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。