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文献和实验Rapid Isotyping of Mouse Monoclonal Antibodies
Determination of class and subclass of monoclonal antibodies (MAbs) is important because several immunochemical and functional properties of antibodies depend on the isotype. Knowledge of the light-chain isotype (κ for 95% or λ
Conjugation of monoclonal antibodies
Conjugation of monoclonal antibodies Prelude: You are free to copy and distribute these documents at will--but please do so in their entirety
【翻译】Development trends for monoclonal antibody cancer therapeutics
were not available, general trends could be discerned. Of the unmodified mAbs with a known isotype, 77 (95%) were IgG, whereas 4 (5%) were IgM, which function primarily through CDC. The majority (80%) of the 61 IgG mAbs with human Fc regions (murine mAbs excluded
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