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文献和实验ARF-Directed Guanine-Nucleotide-Exchange (GEP) Proteins
the action of a guanine nucleotide-exchange protein or GEP, which accelerates the release of bound nucleotide via stabilization of the guanine nucleotide-free protein (9 ).
Historical Overview of Rho GTPases
to regulate a diverse range of cellular processes, including cytoskeletal dynamics, NADPH oxidase activation, cell migration, cell polarity, membrane trafficking, and transcription. The Rho regulators, guanine nucleotide exchange factors (GEFs), GTPase
Biochemical Assays to Characterize Rho GTPases
. These very slow reactions require catalysis in cells by two kinds of regulatory proteins. While the guanine nucleotide exchange factors (GEFs) activate small GTPases by stimulating the exchange of bound GDP for the cellular abundant GTP, GTPase-activating proteins
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