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- 2025年07月14日
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文献和实验HIV envelope glycoprotein (Env) is composed of two non-covalently associated subunits: gp120 and gp41. Panning of phage-displayed antibody libraries against gp140 (covalently linked gp120 and the extracellular portion of gp41) has resulted
Aptamer-Targeted RNAi for HIV-1 Therapy
RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Herein, we demonstrate novel cell type-specific dual inhibitory function anti-gp120 aptamer-siRNA delivery systems for HIV-1 therapy
Anti-c-erb-B-2 Ribozyme for Breast Cancer
growth factor receptor (EGFR) (1 ,2 ) The putative ligand for c-erb -B-2 is thought to be gp30; however, its role in this process remains to be elucidated (3 ) Although EGFR can transform mouse NIH3T3 cells only in the presence of ligand and receptor
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