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- 详细信息
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
MCTR1
- 库存:
10
- 供应商:
TargetMol
- CAS号:
1784701-61-6
- 规格:
50 μg/10 μg/25 μg/100 μg
| 规格: | 50 μg | 产品价格: | ¥12200.0 |
|---|---|---|---|
| 规格: | 10 μg | 产品价格: | ¥2730.0 |
| 规格: | 25 μg | 产品价格: | ¥6450.0 |
| 规格: | 100 μg | 产品价格: | ¥19800.0 |
Product Introduction
Bioactivity
英文名:MCTR1
描述:Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate.

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