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- 文献和实验
- 技术资料
- 保存条件：
Store at 2-8℃，2 years.
- 保质期：
Store at 2-8℃，2 years.
- 英文名：
Tolbutamide
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
64-77-7
- 规格：
100mg
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| 详细描述 |
使用本产品的案例（仅供参考） LC-MS/MS The chromatographic separation was carried out using an C18, 2.1×100 mm , 3.5-μm column, on a LC-30A UFLC system. The column oven temperature was set at 35 C. A mobile phase consisting of 0.025 % formic acid in water (A) and methanol (B) was delivered at a flow rate of 0.2 mL/min using the gradient program. The mass operation parameters were: ion source gas 1 was set at 55 psi, ion source gas 2 at 60 psi, curtain gas at 30 psi, and collision gas at medium. The gradient program using was: 15 % (B) from 0 to 2 min,15-55 % (B) from 2 to 6 min, 55-75 % (B) from 6 to 16 min, 75 % (B) from 16 to 17 min, 75-15 % (B) from 17 to 17.5 min and 15 % (B) from 17.5 to 22 min. A negative Turbo Spray ion source was used in the MS analysis. Temperature was set at 600 C and IonSpray voltage at -4500V. In product ion scan mode, product ions of m/z 663.4, 839.4, 825.4 were searched respectively. Scan range was set at 100-700 Da for m/z 663.4, and 100-850 Da for m/z 839.4 and 825.4. In precursor ion scan mode, precursor ions of m/z 663.4 and 501.3 were searched respectively. Scan range was set at 300-1100, 670-1100 and 750-1100 Da. In both product ion scan mode and precursor ion scan mode, scan rate was set at 200 Da/s, declustering potential (DP) start and DP stop at -100 and -150V, and collision energy (CE) at -36V. In multiple reaction monitoring (MRM) mode, ilexsaponin A1 and its two potential metabolites were monitored simultaneously. The precursor-to-product ion pairs for MRM transitions, DP and CE were optimized at m/z 663.4→ 501.3, -150V and -45V for ilexsaponin A1, m/z 839.4 → 501.3, -40 V and -70 for M1 (a glucuronic acid conjugation product), and m/z 825.4→ 501.3, -70 V and -60V for M2 (a glucose conjugation product), respectively. MRM mode was also used in both metabolic stability study and metabolic enzyme identification, including the precursor-to-product ion pairs for MRM transitions, DP and CE set for pedunculoside (IS) were at m/z 695.4 → 487.3, -120V and -36 V, respectively. 来源文献：Wu L, Kang A, Jin X, Bao Y, Miao P, Lv T, Zhou Z. Ilexsaponin A1: In vitro metabolites identification and evaluation of inhibitory drug-drug interactions. Drug Metab Pharmacokinet. 2021 Oct;40:100415. doi: 10.1016/j.dmpk.2021.100415. Epub 2021 Aug 2. PMID: 34461570. |
| CAS | No.64-77-7 |
| 分子式 | C12H18N2O3S |
| 分子量 | 270.35 |
| 单位 | 瓶 |
| 储存条件 | Store at 2-8℃，2 years. |
| 纯度 | HPLC≥98% |
| 英文名称 | Tolbutamide |
| 中文名称 | 甲苯磺丁脲 |
| 别名 | HLS 831 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Ilexsaponin A1: In vitro metabolites identification and evaluation of inhibitory drug-drug interactions
成员:Wu L; Kang A; Jin X; Bao Y; Miao P; Lv T; Zhou Z
论文因子:2.1 发表期刊:Drug Metab Pharmacokinet pmid:34461570
注意：以上文献 仅供参考
CD77 分子 CD77 常用单克隆抗体或代号： 38.13(BL- A),424/4A11 主要表达细胞： Bac [B] 分子质量(kDa)和结构： Globotriaocylceramide(Gb3) 功 能： 参与凋亡过程中跨膜信号转导 CD77 Aka globotriaosylceraminde, pK blood group Binds to Shiga
CD64 分子 CD64 常用单克隆抗体或代号： MAb32.2,MAb22;(Fcg RI) 主要表达细胞： M [M] 分子质量(kDa)和结构： gp75(IgSF) 功 能： 吞噬、ADCC,Mac活化 CD64 Aka Fc gamma RI High affinity receptor binds to Fc region of IgG
实验77 苍耳的光周期诱导 原理 植物在发育地程中需要有一定的光周期诱导才能进入性器官的分化，从而达到开花结实。苍耳是短日照植物，短的光周期诱导能促使其性器官分化，提早开花结实。 仪器 供短日处理的暗箱或暗室 小花盆 光照自控装置 双筒解剖镜 操作步骤 1．将苍耳种子播种
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